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ProteomicsWells Lab Primary T Cell Surfaceomics
Glycoprotein cell surface capture proteomics of effector T cells following activation as well as co-culture with Tregs and hypoxic culture.
ORGANISM(S): Homo sapiens (Human) 
2022-03-03 | PXD024789 | Pride
Surface proteomics Hypoxia T cells 
MetabolomicsSubcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages
Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis, remains the world's deadliest infectious disease. Sterilizing chemotherapy requires at least 6 months of multidrug therapy. Difficulty visualizing the subcellular localization of antibiotics in infected host cells means t...
2020-12-07 | MTBLS959 | MetaboLights
ProteomicsIdentifying Layilin Interaction Partners
This project aimed to identify the ligand for the cell surface receptor and C-type lectin laylin, a surface receptor with unknown function.
ORGANISM(S): Homo sapiens (Human) 
2022-02-21 | PXD027886 | Pride
T cell C-type lectin Collagen Layilin 
ProteomicsPVRL2 suppresses anti-tumor immunity through PVRIG- and TIGIT-independent pathways
Here, we share discovery proteomics data associated with a larger study to expose new immunoregulatory mechanisms in cancer. PVRL2 was identified in both tumor cells and exosomes, and the role of this surface protein in the immune response to cancer was explored in further studies.
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD044245 | Pride
Immunology Cancer 
ProteomicsGT-stabiligase N-terminomics technology for capturing proteolytic modifications on human cell surfaces
Here we introduce a stabiligase technology that directly identifies neo-proteolytic epitopeson the cell surface of human cells using a glycan-tethered, engineered peptide ligase.
ORGANISM(S): Homo sapiens (Human) 
2023-06-23 | PXD033811 | Pride
Subtiligase protein engineering N-terminomics Proteolysis 
ProteomicsMulti-scale photocatalytic proximity labeling reveals cell surface neighbors on and between cells
Proximity labeling proteomics (PLP) strategies are powerful approaches to yield snapshots of protein neighborhoods. Here, we describe a multi-scale PLP method with adjustable resolution using a commercially available photosensitizer, Eosin Y, which upon visible light illumination, activates differen...
ORGANISM(S): Homo sapiens (Human) Acyrthosiphon pisum (Pea aphid) 
2025-02-17 | PXD051348 | Pride
Chimeric antigen receptor (car) t cells Epidermal growth factor receptor Proximity labeling Photocatalysis Bispecific t cell engager 
ProteomicsLarge bidirectional remodeling of the Myc-induced cell surface proteome in B-cells and prostate cells creates new opportunities for immunotherapy
To identify how MYC overexpression remodels the cell surface proteome in a cell autologous fashion and in different cell types, we investigated the impact of MYC overexpression on ~800 surface proteins in three isogenic model cell lines either of B-cell or prostate cell origin that were engineered t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-08-07 | MSV000085930 | MassIVE
ProteomicsLow Density Lipoprotein Receptor Targeting Chimeras for Membrane Protein Degradation and Enhanced Drug Delivery
Antibody-based therapeutics encompass diverse modalities for targeting tumor cells, among which antibody-drug conjugates (ADCs) and extracellular targeted protein degradation (eTPD) specifically depend on efficient lysosomal trafficking for activity. However, many tumor antigens exhibit poor interna...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD064642 | Pride
Antibody based degradation 
ProteomicsHypoxia induces extensive protein and proteolytic remodeling of the cell surface in pancreatic adenocarcinoma (PDAC) cell lines
A study on the cell surface modifications that occur on pancreatic epithelial cells in a hypoxic tumor microenvironment.
ORGANISM(S): Homo sapiens (Human) 
2026-04-01 | PXD057350 | Pride
Pancreatic cancer 
ProteomicsBroad and thematic remodeling of the surface glycoproteome on isogenic cells tranformed with driving proliferative oncogenes
The cell surface proteome, the surfaceome, is the interface for engaging the extracellular space in normal and cancer cells. Here we apply quantitative proteomics of N-linked glycoproteins to reveal how a collection of some 700 surface proteins is dramatically remodeled in an isogenic breast epithel...
ORGANISM(S): Homo sapiens (Human) 
2020-04-08 | PXD017039 | Pride
Glycoproteomics Mapk signaling pathway Surfaceome Oncogenes 
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