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ProteomicsSILAC Mass Spectrometry of U2AF2 Interactome in Resting and Activated CD4 T cells
T cell activation leads to dramatic changes in cellular phenotype. We used activated human CD4 T cells to study how RNA binding proteins define the post-transcriptional landscape. Using RIPseq, we identified the RNA interactome of U2AF2 and show that U2AF2 binds the majority of transcripts that are...
ORGANISM(S): Homo sapiens (Human) 
2016-04-27 | PXD001846 | Pride
Cd4 t cell activation/mrna splicing/rna-binding proteins/u2af 
ProteomicsFucosylation of HLA-DRB1 regulates CD4+T cell-mediated anti-melanoma immunity and enhances immunotherapy efficacy: CD4+ T Cell Phosphoproteomics
Immunotherapy efficacy is limited in melanoma, and combinations of immunotherapies with other modalities have yielded limited improvements but also adverse events requiring cessation of treatment. In addition to ineffective patient stratification, efficacy is impaired by paucity of intratumoral immu...
ORGANISM(S): Homo sapiens (Human) 
2022-12-16 | PXD038065 | Pride
Phosphoproteomics Fucosylation Melanoma Cd4 t cells Immunotherapy 
ProteomicsFucosylation of HLA-DRB1 regulates CD4+T cell-mediated anti-melanoma immunity and enhances immunotherapy efficacy: Fucoproteomic profiling of CD4 T cells
Immunotherapy efficacy is limited in melanoma, and combinations of immunotherapies with other modalities have yielded limited improvements but also adverse events requiring cessation of treatment. In addition to ineffective patient stratification, efficacy is impaired by paucity of intratumoral immu...
ORGANISM(S): Homo sapiens (Human) 
2022-12-16 | PXD038636 | Pride
Melanoma Fucose Cd4 t cells Immunotherapy 
ProteomicsProtein Interactome of U2AF2 during T cell activation
T cell activation leads to dramatic changes in cellular phenotype. We used activated human CD4 T cells to study how RNA binding proteins define the post-transcriptional landscape. Using RIPseq, we identified the RNA interactome of U2AF2 and show that U2AF2 binds the majority of transcripts that are...
ORGANISM(S): Homo sapiens (Human) 
2016-04-27 | PXD001843 | Pride
Rip mass spectrometry U2af Cd4 t cells Rna-binding proteins 
TranscriptomicsT cell Activation is Regulated by Assembly of an RNA-binding Interactome Centered on the U2AF Heterodimer that Includes ILF2, SRRM2, and SYNCRIP [RIP-seq]
T cell activation leads to dramatic changes in cellular phenotype. We used CD3/CD28-activated human CD4 T cells to study how RNA binding proteins define the post-transcriptional landscape. Using RIPseq, we identified the RNA interactome of U2AF2 and show at the global level that U2AF2 binds the maj...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-62919 | biostudies-arrayexpress
TranscriptomicsT cell Activation is Regulated by Assembly of an RNA-binding Interactome Centered on the U2AF Heterodimer that Includes ILF2, SRRM2, and SYNCRIP [RNA-seq]
T cell activation leads to dramatic changes in cellular phenotype. We used CD3/CD28-activated human CD4 T cells to study how RNA binding proteins define the post-transcriptional landscape. Using RIPseq, we identified the RNA interactome of U2AF2 and show at the global level that U2AF2 binds the maj...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-62920 | biostudies-arrayexpress
TranscriptomicsT cell Activation is Regulated by Assembly of an RNA-binding Interactome Centered on the U2AF Heterodimer that Includes ILF2, SRRM2, and SYNCRIP [RIP-array]
T cell activation leads to dramatic changes in cellular phenotype. We used CD3/CD28-activated human CD4 T cells to study how RNA binding proteins define the post-transcriptional landscape. Using RIPseq, we identified the RNA interactome of U2AF2 and show at the global level that U2AF2 binds the maj...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-62922 | biostudies-arrayexpress
TranscriptomicsT cell Activation is Regulated by Assembly of an RNA-binding Interactome Centered on the U2AF Heterodimer that Includes ILF2, SRRM2, and SYNCRIP [total RNA-array]
T cell activation leads to dramatic changes in cellular phenotype. We used CD3/CD28-activated human CD4 T cells to study how RNA binding proteins define the post-transcriptional landscape. Using RIPseq, we identified the RNA interactome of U2AF2 and show at the global level that U2AF2 binds the maj...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-62921 | biostudies-arrayexpress
ProteomicsEROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling.
The phagocyte NADPH oxidase is critical for host defence, and EROS (Essential for Reactive Oxygen Species) protein is indispensable for expression of its gp91phox-p22phox heterodimer. EROS deficiency in humans is a recently described cause of chronic granulomatous disease (CGD), but its mechanism of...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-30 | PXD025149 | Pride
Nox family Inflammasome Nadph oxidase Ost complex Chaperone T cells P2x receptor Er 
UnknownUrsodeoxycholic acid prevents ventricular conduction slowing and arrhythmia by restoring T-type calcium current in fetuses during cholestasis.
Not available
S-EPMC5608194 | biostudies-literature
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