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ProteomicsCell Surface Protein Atlas - A mass spectrometric-derived cell surface protein atlas
Cell Surface Capture (Wollscheid et al., 2009, Nat.biotec.) was performed on various different cell types in order to characterize the cell surface proteome and to build the Cell Surface Protein Atlas.
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2016-02-16 | PXD000589 | Pride
Cspa Surfaceome Mass spectrometry Cell surface capture 
ProteomicsFc Gamma Receptor (FcγR) Expression and Signaling in the Developing Rat Brain
Maternal antibodies specific for antigens in the developing brain are implicated as risk factors for neurodevelopmental disorders, but how these antibodies interfere with neurodevelopment remain speculative. It has been postulated that immunoglobulin G-immune complexes (IgG-IC) activate Fc gamma rec...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-01-11 | PXD006904 | Pride
Neuron culture Brain Fc gamma receptors 
ProteomicsDe novo Classification of Mouse B Cell Types using Surfaceome Proteotype Maps
System-wide quantification of the cell surface proteotype and identification of extracellular glycosylation sites is challenging when sample is limiting. We miniaturized and automated the previously described Cell Surface Capture technology increasing sensitivity, reproducibility, and throughput. We...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-12-11 | PXD013627 | Pride
Flow cytometry Cell surface capture Cell surface proteome Hrm B-cell development Dda Mouse model Classification Affinity purification Dia Lc-ms Proteotype Autocsc Csc Surfaceome 
ProteomicsCD20 is gatekeeper of human B cell identity and activation state
B cell identity and function is dependent on the proteins residing in the B cell surfaceome and their respective nanoscale organization. Here we show that CD20 is a gatekeeper for B cell identity and function due to its control of the functional nanoscale organization of receptors within the B surfa...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-06-18 | MSV000085605 | MassIVE
ProteomicsProject Grandiose, cell surface protein capture
The aim of Project Grandiose has been to examine the process of somatic cell (specifically, murine fibroblast) conversion to induced pluripotent stem cells, at many levels (proteome, mRNA, DNA methylation, etc.), over the time course of the conversion. This dataset represents the cell surface proteo...
ORGANISM(S): Mus musculus (Mouse) 
2014-11-27 | PXD001456 | Pride
Mouse Ipsc Stem cells Lc-ms/ms 
ProteomicsEx vivo drug response heterogeneity reveals personalized therapeutic strategies for patients with multiple myeloma
Multiple myeloma (MM) is a plasma cell malignancy defined by complex genetics and extensive patient heterogeneity. Despite a growing arsenal of approved therapies, MM remains incurable and in need of guidelines to identify effective personalized treatments. Here, we survey the ex vivo drug and immun...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-06 | MSV000088992 | MassIVE
ProteomicsA proteogenomic resource enabling integrated analysis of Listeria genotype-proteotype-phenotype relationships
Listeria monocytogenes is an opportunistic foodborne pathogen responsible for listeriosis, the third most common foodborne disease. Many different Listeria strains and seroptypes exist, however a proteogenomic resource which would provide a basis for bridging the gap in the molecular understanding b...
ORGANISM(S): Listeria Monocytogenes Egd-e (ncbitaxon:169963) Listeria Monocytogenes Str. Scott A (ncbitaxon:1027396) 
2019-06-01 | MSV000083881 | MassIVE
ProteomicsSimultaneous targeted and discovery-driven clinical proteotyping using hybrid-PRM/DIA
Background MS-based proteotyping has been widely used for biomarker discovery. However, the clinical/translational proteotyping community requires strategies that not only enable the discovery of novel biomarker candidates but also increase the likelihood of establishing these protein-based biomarke...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000092996 | MassIVE
ProteomicsA Peptidomimetic Antibiotic Interacts with the Periplasmic Domain of LptD from Pseudomonas aeruginosa
Gram-negative bacterial infections are causing increasing levels of morbidity due to the rise of resistance to established antibiotics. New antibiotic classes with distinct molecular mode of action are therefore required. Recently, a family of macrocyclic peptidomimetics was discovered that target t...
ORGANISM(S): Pseudomonas Aeruginosa Pao1 (ncbitaxon:208964) 
2020-02-04 | MSV000084898 | MassIVE
ProteomicsThanatin Targets the Inter-Membrane Protein Complex Required for Lipopolysaccharide Transport in Escherichia coli
With the increasing resistance of many Gram-negative bacteria to existing classes of antibiotics, identifying new paradigms in antimicrobial discovery is an important research priority. Of special interest here are the proteins required for the biogenesis of the symmetric Gram-negative bacterial out...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2020-02-04 | MSV000084897 | MassIVE
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