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ProteomicsKetohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer
Harmful effects of high fructose intake on health have been widely reported in epidemiological and laboratory studies. Although it has been reported that fructose promotes cancer development and progression, little is known about the underlying molecular mechanisms. Here, we found that fructose trig...
ORGANISM(S): Homo sapiens (Human) 
2020-11-09 | PXD021035 | Pride
Breast cancer metastasis  fructose  ketohexokinase-a  nuclear translocation  serine kinase 
ProteomicsIntestinal alcohol abuse sorted dendritic cells proteomics
Consumption of ethanol has detrimental effects on gastric organs such as the intestine. To demonstrate the deleterious effect of alcohol, we sacrificed isobaric feeding or ethanol feeding mice and sorted the dendritic cells from their intestine organ. The dendritic cells were analyzed by a small-sca...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-16 | PXD033700 | Pride
Dendritic cell proteomics Intestinal alcohol effect Ethanol mice 
ProteomicsMethod development for simplified High-Throughput Plasma Proteomics
We developed a simplified proteomics sample preparation method that increased the sensitivity and reproducibility of large-scale plasma samples. Peptide loss was reduced while sensitivity was increased by eliminating the peptide clean-up step and using disposable trap column tips. The simplified Hig...
ORGANISM(S): Homo sapiens (Human) 
2023-04-03 | PXD038669 | Pride
Shtpp Simplified high-throughput plasma proteomics 
ProteomicsDifferential quantitative proteome analysis of cerebellar flocculus on oculomotor behavior training mouse model
Oculomotor behavior model system is commonly employed to study the neural circuits and the cellular mechanisms underlying neural integration related to motor behavior. The flocculus is a small lobe at the posterior border of the middle cerebellar and involved in motor control to aid in the oculomoto...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-20 | PXD008433 | Pride
Tmt labeling Flocculus Oculomotor behavior mouse model 
ProteomicsProteomic profiling of mouse Paneth cells microdissected from small intestinal tissue
Paneth cells are antimicrobial peptide-secreting cells located at the base of the crypts of the small intestine. The proteome of Paneth cells is not well defined because of their co-existence with stem cells making it difficult to culture Panth cells alone in vitro. Using a simplied toluidine blue O...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-12 | PXD034143 | Pride
Paneth cell Mouse small intestine Proteomics Laser capture microdissection Toluidine blue Villi 
ProteomicsTargeted proteomics of signal pathways in BV2 microglial cell activation
Microglia become activated by disturbances in the homeostasis of their local microenvironment. While there are varying degrees of microglia activation, a pro-inflammatory reactive state induced by exposure to stimuli like LPS and IFN-γ. In this study, using label-free PRM approach which is allowing ...
ORGANISM(S): Mus musculus (Mouse) 
2017-08-09 | PXD006556 | Pride
Targeted protoemics Quantitative analysis Label-free prm Bv2 activation 
ProteomicsIn-depth quantitative proteomics of signal pathways in BV2 microglial cell activation
Microglia become activated by disturbances in the homeostasis of their local microenvironment. While there are varying degrees of microglia activation, a pro-inflammatory reactive state induced by exposure to stimuli like LPS and IFN-γ. In this study, we identified a total of 5497 proteins in whole ...
ORGANISM(S): Mus musculus (Mouse) 
2017-08-09 | PXD006558 | Pride
Dimethylation labeled quantification Quantitative analysis Bv2 activation 
ProteomicsIn-depth characterization of the secretome of mouse CNS cell lines by LC-MS/MS without prefractionation
Microglia, astrocytes, and neurons, which have important functions in the central nervous system, communicate mutually to generate a signal through secreted proteins or small molecules, but many of which have not been identified. Because establishing a reference for the secreted proteins from CNS ce...
ORGANISM(S): Mus musculus (Mouse) 
2015-08-04 | PXD001597 | Pride
Neuron Cns cell line Proteome profile Microglia Label-free quantitation Secretome Astrocyte 
ProteomicsAstaxanthin Supplementation Counters Exercise-Induced Decreases in Immune- Related Plasma Proteins
Astaxanthin is a dark red keto-carotenoid found in aquatic animals such as salmon and shrimp, and algae (Haematococcus pluvialis). Astaxanthin has a unique molecular structure that may facilitate anti-oxidative, immunomodulatory, and anti-inflammatory effects during physiological stress. The primary...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD040503 | Pride
Astaxanthin High-throughput plasma proteomics Shtpp 
OtherProteomic analysis of mouse astrocytes and their secretome by a combination of FASP and StageTip-based, high pH, reversed-phase fractionation.
Data from ProteomeXchange, PXD ID: PXD000501. C8-D1A cells analyzed. Experiment: C8D1A_secretome_set1_2, file: 20130530_C8D1A_secretome_set1_F6_2.mzml. Published as part of Proteomics. 2014 Apr 17 . From the Abstract: {{i}} Astrocytes are the most abundant cells in the CNS, but their function remai...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32320000882 | GPMDB
Resource Reanalysis 
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