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ProteomicsRegulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα
Progenitor cells at the basal layer of skin epidermis play an essential role in maintaining tissue homeostasis and enhancing wound repair in skin. The proliferation, differentiation, and cell death of epidermal progenitor cells have to be delicately regulated, as deregulation of this process can lea...
ORGANISM(S): Homo sapiens (Human) 
2020-05-13 | PXD015673 | Pride
Deubiquitination Kdf1 Silac Skin Ikkα Epidermal differentiation Qe-ms 
MetabolomicsProfiling the metabolome of uterine fluid for early detection of ovarian cancer

Ovarian cancer (OC) causes high mortality in women because of ineffective biomarkers for early diagnosis. Here, we perform metabolomics analysis on an initial training set of uterine fluid from 96 gynecological patients. A seven-metabolite-marker panel consisting of vanillylmandelic acid, norepin...

2023-03-06 | MTBLS4861 | MetaboLights
ProteomicsViperin Mediates Coxsackievirus B3-induced Acute Heart Failure via KCNQ1 Ion Channel
Given that CVB3 is able to impair myocardial contractility, which finally leads to acute heart failure (AHF) and even sudden death, we tried to analyze the related myocardial function of these groups of mice
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD036898 | Pride
Viperin  cvb3  acute heart failure  sgk1 
ProteomicsIntegrative analysis of transcriptome and proteome provides insights into adaptation to cadmium stress in Sedum plumbizincicola
Sedum plumbizincicola, a cadmium (Cd) hyperaccumulating herbaceous plant, can accumulate large amounts of Cd in the above-ground tissues without being poisoned. However, the molecular mechanisms regulating the processes are not fully understood. In this study, Transcriptional and proteomic analyses ...
ORGANISM(S): Sedum Plumbizincicola 
2021-09-21 | PXD028688 |
ProteomicsPRM-Based Quantitative Proteome Profiling of Aqueous Humor of Diabetic Retinopathy
Diabetic retinopathy (DR) is a leading cause of irreversible vision impairment and blindness. To explore the dynamics of aqueous humor (AH) protein profiles during four stages from non-diabetic individuals to proliferative diabetic retinopathy patients, especially to improve our understanding of pat...
ORGANISM(S): Homo Sapiens 
2024-07-04 | PXD053634 |
ProteomicsDown-regulated Glutathione Peroxidase-4 by Graphene Quantum Dots Inducing Ferroptosis in Macrophages
to explore the mechanism, we analyzed the differences in the protein profile of macrophages using tandem mass tags (TMT) proteomics.
ORGANISM(S): Mus Musculus 
2020-12-23 | PXD023303 |
ProteomicsThe aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK
The activity of 5’-adenosine monophosphate-activated protein kinase (AMPK) is inversely correlated with the cellular availability of glucose. When glucose levels are low, the glycolytic enzyme aldolase is not bound to fructose-1,6-bisphosphate (FBP) and, instead, signals to activate lysosomal AMPK. ...
ORGANISM(S): Oryctolagus Cuniculus 
2022-08-10 | PXD035968 |
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