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ProteomicsHuman, melanoma, p62/SQSTM1, quantitative proteomics
p62/SQSTM1 was identified as a modulator of metastatic genes selectively enriched in melanoma in autophagy independent manner. iTRAQ quantitative proteomic approach was performed in melanoma cell lines (SK-Mel-103 and UACC-62) deficient for p62 to identify downstream effectors of p62. Similar studie...
ORGANISM(S): Homo sapiens (Human) 
2022-02-28 | PXD006650 | Pride
Human Ap-ms P62/sqstm1 Melanoma cell lines Quantitative proteomics Lc-ms/ms 
ProteomicsPolyamine-dependent metabolic shielding regulates U2 snRNP SF3 subcomplex phosphorylation and alternative splicing
Metabolites are central to cellular homeostasis. Whereas much emphasis has been placed on their relevance to meet energetic and biosynthetic demands, metabolic intermediates also function as signaling molecules. Here we show that polyamines, small polycations that are essential for cell biology, reg...
ORGANISM(S): Homo sapiens (Human) 
2025-11-11 | PXD046107 | Pride
Tmt Human phosphoproteome Poliamines Alternative splicing 
ProteomicsCharacterization of plasma circulating small extracellular vesicles in patients with metastatic solid tumors and newly diagnosed brain metastasis
Brain metastases are critical for outcomes and quality of life in almost 50% of oncological patients, generally associated with a poor short-term prognosis. Early or preventive diagnosis of this complication represents an unmet need. There is a necessity of discovering new biomarkers that could aid ...
ORGANISM(S): Homo sapiens (Human) 
2022-05-08 | PXD032767 | Pride
Exosomes Plasma Human Brain metastasis 
ProteomicsQuantitative proteomics of CELF1-silenced human melanoma cell lines
CELF1 was silenced in two human melanoma cell lines (SKMEL-103 and UACC-62, indicated as 9M and 17M, respectively) using short hairpin RNA (tag 114). As control scrambled non targeting shControl transduced cell were used (tag 115).
ORGANISM(S): Homo sapiens (Human) 
2017-12-21 | PXD003112 | Pride
Human Lc-ms/ms Velos orbitrap Melanoma Itraq Celf1 
ProteomicsDisruption of basal cell identity by Rank signaling drives mammary tumorigenesis
Rank signaling regulates mammary gland development and epithelial cell differentiation. Rank receptor is expressed by mammary basal and luminal populations, but, unlike luminal Rank, the contribution of basal Rank signaling to MG homeostasis remains poorly studied. We have combined timely regulated ...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-02 | PXD054102 | Pride
Breast cancer Basal cell Identity infidelity Rank Mouse Mammary gland 
ProteomicsEmilin1 degradation and secretion in exosomes inactivate its tumor- and metastasis-suppressive role in melanoma mouse models
Several studies have demonstrated that melanoma-derived exosomes home in sentinel lymph nodes favoring metastasis. Here, we determined the proteomic signature in exosomes derived from lymph node metastatic models. We found a signature of genes over-expressed and proteins hyper-secreted in exosomes r...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-16 | PXD018891 | Pride
Exosomes Melanoma Ltq velos orbitrap Emilin 
ProteomicsExosomes and small microvesicles are key regulators of non-cell autonomous intercellular communication in senescence
Senescence is a cellular phenotype present in health and disease, characterized by an irreversible cell cycle arrest and an inflammatory response, denominated senescence-associated secretory phenotype (SASP). The SASP is important in influencing the behaviour of neighbouring cells and altering the m...
ORGANISM(S): Homo sapiens (Human) 
2019-06-25 | PXD010379 | Pride
Mass spectrometry  label free  exosomes  small extracellular vesicles  ev  paracrine senescence  ois  ddis  aging  tumour suppressor  ifitm3 
ProteomicsUse of lymph-circulating extracellular vesicles as surrogate markers of melanoma progression and BRAFV600E mutation
Liquid biopsies are becoming imperative on early patient diagnosis, prognosis and evaluation of residual disease. The use of circulating extracellular vesicles (EVs) as surrogate markers of tumor progression could be a powerful tool in the clinical setting. EVs in plasma have emerged as a non-invasi...
ORGANISM(S): Homo sapiens (Human) 
2019-03-13 | PXD012042 | Pride
Extracellular vesicles Plasma Patients Serome Lc msms Melanome 
ProteomicsUbiquitin proteomics reveals critical targets of the Nse1 RING domain in rDNA and genome stability
Ubiquitination controls most cellular processes, and its deregulation is associated to many pathologies. The Nse1 subunit in the Smc5/6 complex contains a RING domain with ubiquitin E3 ligase activity and important functions in genome integrity. However, Nse1-dependent ubiquitin targets remain large...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-05-05 | PXD028669 | Pride
Nse1 Ubiquitination 
ProteomicsImpact of high fat diet and platelet activation on pre-metastatic niche formation
Metastasis involves dynamic interactions between tumor cells and the tumor microenvironment. Obesity has emerged as a significant contributor to tumor progression, particularly in breast cancer (BC). This study explores the impact of obesity on BC metastasis, focusing on the role of platelets and th...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-22 | PXD051176 | Pride
Platelets Breast cancer Pre-metastatic niche Itraq High fat diet 
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