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ProteomicsIdentification of gasderminD interacting proteins by mass spectrometry
Gasdermin D (GSDMD)-mediated macrophage pyroptosis plays a critical role in inflammation and host defense. Plasma membrane perforation elicited by caspase-cleaved GSDMD N-terminal domain (GSDMD-NT) triggers membrane rupture and subsequent pyroptotic cell death, resulting in release of pro-inflammato...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD039133 | Pride
Fasn Palmitoylation Gsdmd Gasdermin d Immunoprecipitation Pyroptosis  lc-msms 
ProteomicsLarge Aging Neutrophil-Derived Vesicles (LAND-Vs) Perpetuate Host Anti-Inflammatory Response to Facilitate Inflammation Resolution
Precise regulation of the duration and extent of inflammation is crucial for balancing pathogen elimination and preventing tissue damage. The mechanisms underlying inflammation resolution are not yet fully understood. Here, we reveal that neutrophils, typically known for their pro-inflammatory role ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-23 | PXD048609 | Pride
Land-v Human neutrophils Human vesicle 
MetabolomicsThe trans-omics landscape of COVID-19
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 2...
2021-10-06 | MTBLS2542 | MetaboLights
ProteomicsProteomic response of S. aureus to alpha-mangostin
S. aureus isolate was inoculated and cultured to exponential growth phase (OD600 at 0.5) in TSB and divided into two groups, the control group and the drug treated group. alpha-mangostin was added to the drug treated group until a final concentration of 1/2× MIC reached, and DMSO added in the contro...
ORGANISM(S): Staphylococcus Aureus 
2022-10-17 | PXD037518 |
ProteomicsThe ferruginous hemeprotein HhuH facilitates the detoxification of cadmium and chromium in Stenotrophomonas sp. SY1
Stenotrophomonas sp. SY1 showed the highly efficient detoxification to cadmium and chromium. Thus, the purpose of this project is to clarify the mechanism of detoxification to cadmium and chromium in strain SY1.
ORGANISM(S): Stenotrophomonas Sp. Sy1 
2024-02-29 | PXD050232 |
ProteomicsDeep Multilayer Tissue Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression, human data
The molecular networks underlying Alzheimer’s disease (AD) are not well-defined. We present temporal profiling of >14,000 proteins and >34,000 phosphosites at the asymptomatic and symptomatic stages of AD, deep proteomics analysis of transgenic mouse models.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-17 | MSV000096123 | MassIVE
ProteomicsTRIM55 promotes noncanonical NF-kB signaling and B-cell-mediated immune responses by coordinating p100 ubiquitination and processing
The ubiquitination-dependent processing of NF-B2 (also known as p100) is a critical step in the activation of the noncanonical NF-B pathway. We investigated the molecular mechanisms regulating this process and showed that TRIM55 was the ubiquitin E3 ligase that mediated the ubiquitination of p100 ...
ORGANISM(S): Mus Musculus 
PXD044895 |
ProteomicsStudy the effect of licorice-yuanhua combination on the gut mucosal barrier
licorice-yuanhua is one of the incompatible herbal pairs in the "Eighteen incompatible Medicaments" of traditional Chinese Medicine. In this study, Chemical compounds in licorice and yuanhua were used to treat the LS174T cells and iTRAQ labled proteomics study was conducted.
ORGANISM(S): Homo Sapiens 
PXD018456 |
ProteomicsSIRT1 binding proteins in human first trimester villi and HTR8/SVneo cells
In this study, we investigated the potential downstream target proteins in trophoblasts that were regulated by SIRT1 through modulation of acetylation. To this end, the IP products of SIRT1 in the lysate of human first-trimester villous tissue and HTR8/SVneo cells were subjected to proteomics analys...
ORGANISM(S): Homo Sapiens 
2021-06-08 | PXD026574 |
ProteomicsHierarchical Helical Carbon Nanotube Fibre as a Bone Integrating ACL Replacement
Hierarchically assembled helical fiber integrates effectively with bones
ORGANISM(S): Oryctolagus Cuniculus Homo Sapiens 
2023-03-17 | PXD032128 |
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