Sort   by:  
 Page size 
ProteomicsTumor-Derived Exosomal CCT6A Serves as a Matchmaker Introducing Chemokines to Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma
CCT6A is a key subunit of the TRiC complex and is responsible for the folding and maturation of approximately 10% of newly synthesized proteins in cells. Given that different TRiC subunits exhibit substrate specificity, we hypothesized that CCT6A might act as a specific binding subunit. To test this...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD057101 | Pride
Human  pdac cell line  lc-ms  knockdown of cct6a 
ProteomicsTumor-Derived Exosomal CCT6A Serves as a Matchmaker Introducing Chemokines to Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma
M2-polarized tumor-associated macrophages (TAMs) are a key factor contributing to the poor prognosis of pancreatic ductal adenocarcinoma (PDAC). While various factors within the tumor microenvironment drive their formation, the role of PDAC-derived exosomes in this process remains unclear. We aim to...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD056403 | Pride
Exosome Cct6a Pdac 
UnknownRelative exchangeable copper, a high-quality biomarker for differentiation of Traditional Chinese Medicine syndrome in Wilson's disease.
Not available
S-EPMC11462529 | biostudies-literature
ProteomicsLC-MS/MS analysis of S100A1-interacting proteins
Immune checkpoint blockade (ICB) has revolutionized cancer treatment, but the therapeutic response is highly heterogeneous. A potential mode of resistance is tumor-intrinsic mechanisms leading to an immunosuppressive tumor microenvironment. However, the underlying interactive network remains elusive...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD059275 | Pride
Lc-ms/ms Mouse S100a1 Tumor 
MetabolomicsMetabolic Reprogramming in Tumor-Associated Macrophages during Murine Hepatocellular Carcinoma Progression

To investigate the impact of Wdr4 on the metabolic reprogramming of tumor-associated macrophages (TAMs) in hepatocellular carcinoma (HCC), we established an orthotopic HCC model in Wdr4-f/f and Wdr4 conditional knockout (Wdr4-cKO) mice. TAMs were subsequently isolated via flow cytometry-based cel...

2025-09-28 | MTBLS12764 | MetaboLights
TranscriptomicsThe Complete Genome of a Single Individual by Massively Parallel DNA Sequencing
The association of genetic variation with disease and drug response, together with improvements in nucleic acids technologies, has given great optimism for the impact of 'genomic medicine'. However, the formidable size of the diploid human genome has prevented the routine application of sequencing ...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10668 | biostudies-arrayexpress
ProteomicsLactate remodulates the OXPHOS of Tregs by inducing N-glycosylation in mitochondria via transcription and translocation of MGAT1
Proteomic data of control and lactate-treated Naive Treg and Memory Treg
ORGANISM(S): Homo Sapiens 
PXD056590 |
ProteomicsATAD2 is a Potential Immunotherapy Target for Patients with Small Cell Lung Cancer Harboring HLA-A*0201
To identify the immune peptides in SCLC tumour cells that can be processed and presented by HLA-I, we performed LC–MS/MS analysis on 11 SCLC cell lines, representing the heterogeneity of SCLC subtypes. Ten of the cell lines were confirmed positive for HLA-I, and one was HLA-I-deficient. To analyse c...
ORGANISM(S): Homo Sapiens 
2024-11-26 | PXD058303 |
UnknownSelection criteria for large core trials: rationale for the ANGEL-ASPECT study design.
Not available
S-EPMC8785010 | biostudies-literature
Sort   by:  
 Page size