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ProteomicsPROCAL: A set of 40 peptide standards for retention time indexing, column performance monitoring and collision energy calibration
We describe PROCAL (ProteomeTools Standard), a set of 40 synthetic peptides that span the entire hydrophobicity range of tryptic digests, enabling not only accurate determination of retention time indices but also monitoring of chromatographic separation performance over time. The fragmentation char...
ORGANISM(S): artificial sequences 
2017-09-07 | PXD006832 | Pride
Retention time kit Peptide standard Retention time calibration Proteometools Synthetic peptide 
ProteomicsProteomeTools – Part II - Prosit: proteome-wide prediction of peptide tandem mass spectra by deep learning
"The ProteomeTools project aims to derive molecular and digital tools from the human proteome to facilitate biomedical and life science research. Here, we describe the second iteration of the generation and multimodal LC-MS/MS analysis of >220,000 synthetic tryptic peptides representing nearly all c...
ORGANISM(S): Homo sapiens (Human) 
2019-05-21 | PXD010595 | Pride
Proteome tools" Fusion lumos "synthetic peptides Proteometools Peptide standards 
ProteomicsProteomeTools - Building ProteomeTools based on a complete synthetic human proteome
The ProteomeTools project aims to derive molecular and digital tools from the human proteome to facilitate biomedical and life science research. Here, we describe the generation and multimodal LC-MS/MS analysis of >350,000 synthetic tryptic peptides representing nearly all canonical human gene produ...
ORGANISM(S): Homo sapiens (Human) 
2017-02-09 | PXD004732 | Pride
Proteometools Synthetic Srm Prm Mrm Human proteome Peptides Spectral library 
ProteomicsProteomeTools – Part III - HLA Class I & II & non-tryptic peptides
The ProteomeTools project aims to derive molecular and digital tools from the human proteome to facilitate biomedical and life science research. Here, we describe the third iteration of the generation and multimodal LC-MS/MS analysis of >305,000 synthetic non-tryptic peptides representing HLA Class ...
ORGANISM(S): Homo sapiens (Human) 
2021-04-26 | PXD021013 | Pride
Hla Aspn Hla class ii Proteometools Reference standards Hla class i Synthetic peptides Lysn 
ProteomicsProteomeTools Part V - TMT labeled non-modified non-tryptic peptides
The ProteomeTools project aims to derive molecular and digital tools from the human proteome to facilitate biomedical and life science research. Here, we describe the the generation and multimodal LC-MS/MS analysis of >300,000 synthetic non-tryptic peptides labeled with tandem mass tags (TMT6plex).
ORGANISM(S): Homo sapiens (Human) 
2021-04-26 | PXD023120 | Pride
Synthetic peptide Tmt Proteometools Tandem mass tag 
ProteomicsProteomeTools Part IV - TMT labeled non-modified tryptic peptides
The ProteomeTools project aims to derive molecular and digital tools from the human proteome to facilitate biomedical and life science research. Here, we describe the the generation and multimodal LC-MS/MS analysis of >500,000 tryptic synthetic peptides labeled with tandem mass tags (TMT6plex).
ORGANISM(S): Homo sapiens (Human) 
2021-01-11 | PXD023119 | Pride
Synthetic peptide Tmt Proteometools Tandem mass tag 
ProteomicsChemical and phosphoproteomics illuminate the cellular mode of action of AKT inhibitors
Due to its key role in dysregulated cellular signaling in cancer, AKT has been subject to intense drug discovery efforts leading to small molecule inhibitors investigated in clinical trials, notably breast cancer. To shed more light on how these drugs exert their therapeutic effects, we integrated c...
ORGANISM(S): Homo Sapiens 
2022-01-21 | PXD015188 | panorama
ProteomicsSystematic characterization of 21 post-translational modification using synthetic peptides
The data presented in this study in the - context of the ProteoemTools project - is based on the synthesis of about 5000 synthetic peptides carrying 21 different post-translational modifications to systematically characterize their chromatographic and mass spectrometric properties using multimodal L...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-04-05 | MSV000091649 | MassIVE
ProteomicsProsit: Proteome-wide prediction of peptide tandem mass spectra by deep learning
In this study, we extended the ProteomeTools peptide library (PROPEL, see PXD004732 and PXD010595) to train a deep neural network resulting in chromatographic retention time and fragment ion intensity predictions for (tryptic) peptides that exceed the quality of the experimental data.
ORGANISM(S): Drosophila Melanogaster (ncbitaxon:7227) Escherichia Coli (ncbitaxon:562) Saccharomyces Cerevisiae (ncbitaxon:4932) Homo Sapiens (ncbitaxon:9606) Caenorhabditis Elegans (ncbitaxon:6239) 
2021-03-12 | MSV000087047 | MassIVE
ProteomicsProteomeTools â?? Part II - Prosit: proteome-wide prediction of peptide tandem mass spectra by deep learning
"The ProteomeTools project aims to derive molecular and digital tools from the human proteome to facilitate biomedical and life science research. Here, we describe the second iteration of the generation and multimodal LC-MS/MS analysis of >220,000 synthetic tryptic peptides representing nearly all c...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-07-21 | MSV000085805 | MassIVE
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