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ProteomicsProteomic signature of neuroblastoma cells UKF-NB-4 reveals key role of lysosomal sequestration and the proteasome complex in acquiring chemoresistance to cisplatin
Cisplatin (CDDP) is a widely used agent in the treatment of neuroblastoma. Unfortunately, the development of acquired chemoresistance limits its clinical use. To gain a detailed understanding of the mechanisms underlying the development of such chemoresistance, we comparatively analysed established ...
ORGANISM(S): Homo sapiens (Human) 
2019-01-02 | PXD012132 | Pride
Chemoresistance V-atpases Lysosomes Neuroblastoma Cisplatin Proteomics 
ProteomicsDevelopment and validation of a secretome-specific prognostic and predictive gene expression signature for colorectal cancer
Relapse and metastatic progression is a frequent event in colorectal cancer patients detected at early stages. The risk of recurrence requires the development of new biomarkers to correctly predict biological behavior of early stage II and stage III patients and their response to adjuvant chemothera...
ORGANISM(S): Homo sapiens (Human) 
2022-12-27 | PXD032899 | Pride
Prognostic signature Stage stratification Secreted proteins Colorectal cancer Metastasis 
ProteomicsProteomic and in silico analyses of the influence of dextran synthesis on the adaptation of Leuconostoc lactis AV1n to temperature change
Leuconostoc lactis is found in vegetables, fruits, and meat and is used by the food industry in the preparation of dairy products, wines and sugars. We have previously demonstrated, that the dextransucrase (DsrLL) of Lc. lactis AV1n produces a high molecular weight dextran from sucrose, indicating i...
ORGANISM(S): Leuconostoc lactis 
2022-12-27 | PXD037250 | Pride
Leuconostoc Lactic acid bacteria Proteomic Dextran Exopolysaccharides 
ProteomicsIntercellular Transmission of a Synthetic Bacterial Cytotoxic Prion-Like Protein in Mammalian Cells.
bacterial amyloidosis, prion-like, RepA-WH1, intercellular transmission,proteotoxic cross-aggregation
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-05-26 | PXD018245 | Pride
Bacterial amyloidosis Repa-wh1 Prion-like Intercellular transmission Proteotoxic cross-aggregation 
ProteomicsCirculating endoglin induces hypertension via the upregulated expression of BMP4
Endoglin is a membrane glycoprotein primarily expressed by the vascular endothelium and involved in cardiovascular diseases. Upon the proteolytic processing of the membrane-bound protein, a circulating form of endoglin (soluble endoglin, sEng) can be released, and high levels of sEng have been obser...
ORGANISM(S): Homo sapiens (Human) 
2020-04-23 | PXD016228 | Pride
Tgf-β Endothelial cells Preeclampsia Hypertension Endoglin Hht Bmp4 
UnknownAn updated examination of the perception of barriers for pharmacogenomics implementation and the usefulness of drug/gene pairs in Latin America and the Caribbean.
Not available
S-EPMC10213898 | biostudies-literature
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