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MetabolomicsAMPK activation induces RALDH+ tolerogenic dendritic cells by rewiring glucose and lipid metabolism.
Dendritic cell (DC) activation and function are underpinned by profound changes in cellular metabolism. Several studies indicate that the ability of DCs to promote tolerance is dependent on catabolic metabolism. Yet the contribution of AMP-activated kinase (AMPK), a central energy sensor promoting c...
2024-08-16 | MTBLS10647 | MetaboLights
UnknownNew Heteroleptic Ruthenium(II) Complexes with Sulfamethoxypyridazine and Diimines as Potential Antitumor Agents.
Not available
S-EPMC6600252 | biostudies-literature
ProteomicsChikungunya virus phosphoproteomics
SILAC-labeled MRC-5 cells were seeded in 75-cm2 flasks 1 day before infection with CHIKV-LS3 [1] at MOI 5. One hour post infection (h p.i.), the inoculum was removed and replaced with SILAC DMEM containing 2% dialyzed FBS, 0.280 mM arginine, 0.384 mM lysine, 0.5 mM proline, 25 mM HEPES, 2 mM L-Gluta...
ORGANISM(S): Homo sapiens (Human) 
2022-02-28 | PXD009381 | Pride
Chikungunya virus chikv phosphoproteomics 
ProteomicsDevelopment of inhibitors, probes, and PROTAC provides a complete toolbox to study PARK7 in the living cell
The innovation of combined chemical tools, such as small molecule inhibitors, activity-based probes (ABPs), and proteolysis targeting chimeras (PROTACs) for a specific target, not only advances clinical drug discovery but also provides a chemical toolbox to study the diverse biological perspective o...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD047093 | Pride
Park7 Small molecule inhibitors Protacs Activity-based probes 
ProteomicsCellular Validation of Chemically Improved Inhibitor Identifies Monoubiquitination on OTUB2
Ubiquitin thioesterase OTUB2, a cysteine protease from the ovarian tumor (OTU) deubiquitinase superfamily, is associated with enhanced expression during tumor progression and metastasis. Development of OTUB2 inhibitors is therefore believed to be therapeutically important, yet potent and selective s...
ORGANISM(S): Homo sapiens (Human) 
2023-06-27 | PXD041346 | Pride
Otub2 Small-molecule inhibitor Monoubiquitination 
ProteomicsC. difficile strain 630 flagellin C modifications
In proteomics, the study of post-translational modifications often relies on some type of enrichment strategy. Here, we show that an approach that is commonly used in phosphoproteomics (Immobilised Metal Affinity Chromatography (Fe3+-IMAC)) also enriches for peptides with a unique post-translational...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2022-04-04 | PXD029552 | Pride
C. difficile Phosphoproteomics Flagellin 
ProteomicsRetinal proteomics of a mouse model of dystroglycanopathies shows changes in different photoreceptor regions
Mutations in the POMT1 gene, encoding a protein O-mannosyltransferase essential for alpha-dystroglycan (α-DG) glycosylation, are frequently observed in a group of rare congenital muscular dystrophies, collectively known as dystroglycanopathies. However, it is hitherto unclear whether the effects se...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-10 | PXD023704 | Pride
Mouse model Dystroglycanopathies Photoreceptor 
UnknownThe alphavirus nonstructural protein 2 NTPase induces a host translational shut-off through phosphorylation of eEF2 via cAMP-PKA-eEF2K signaling.
Not available
S-EPMC9997916 | biostudies-literature
ProteomicsCharacterization of the Clostridioides difficile 630Δerm putative Pro-Pro endopeptidase CD1597
Clostridioides difficile is the leading cause of antibiotic-associated infections worldwide. Within the host, C. difficile can transition from a sessile to a motile state by secretion of PPEP-1, which releases the cells from the intestinal epithelium by cleaving adhesion proteins. PPEP-1 belongs to ...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2024-05-27 | PXD052347 | Pride
Tmtpro Proteomics Sporulation Clostridioides difficile Proteases Pro-pro endopeptidases 
ProteomicsTemporal quantitative proteomics of Chikungunya virus infected cells
To better understand the complex CHIKV-host interplay we used stable isotope labeling with amino acids in cell culture (SILAC) and LC-MS/MS to define the temporal dynamics of the cellular response to infection. Using samples harvested at 8, 10 and 12 hours post infection, over 4700 proteins were ide...
ORGANISM(S): Cercopithecidae (Old World monkeys) 
2015-03-16 | PXD001330 | Pride
Silac Chikungunya virus Quantitative proteomics Lc-msms 
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