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ProteomicsEndothelial ICAM-1 adhesome recruits CD44 for optimal regulation of human cytotoxic T lymphocyte extravasation
The endothelial lining of blood vessels is covered with a thin polysaccharide coat called the glycocalyx. This layer of polysaccharides contains hyaluronan that forms a protective coat on the endothelial surface. Upon inflammation, leukocytes leave the circulation and enter inflamed tissue by crossi...
ORGANISM(S): Homo sapiens (Human) 
2025-09-30 | PXD036581 | Pride
Cd44 Cytotoxic t cell Inflammation Glycosaminoglycans Endothelial cells Transcellular Transendothelial migration Hyaluronic acid Hyaluronan Glycocalyx 
ProteomicsMKL1 deficiency results in a neutrophil motility defect with impaired actin polymerization and excessive degranulation
Megakaryoblastic leukemia 1 (MKL1) promotes the regulation of essential cell processes, including actin cytoskeletal dynamics by co-activating serum response factor. Recently, the first human case with MKL1 deficiency has been identified, leading to a novel primary immunodeficiency. We report a seco...
ORGANISM(S): Homo sapiens (Human) 
2025-09-30 | PXD014633 | Pride
Mkl1 Actin poymerization Neutrophils Srf Mrtf-a 
ProteomicsDynamic interactions of RNA binding proteins to human cytokine mRNA govern T cell responses
Effective T cell responses against infections and tumors depend on the production of effector molecules, including the key pro-inflammatory cytokines IFN-γ, TNF-α and IL-2. Recent studies revealed that post-transcriptional events determine the magnitude and duration of cytokine production in T cells...
ORGANISM(S): Homo sapiens (Human) 
2023-04-20 | PXD028171 | Pride
Rna-binding proteins 
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