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ProteomicsCell surface interactome analysis identifies TSPAN4 as a negative regulator of PD-L1 in melanoma
PD-L1 functions as a co-inhibitory checkpoint ligand constraining anti-tumor immunity by binding to PD-1 on immune cells. Although antibody blockade therapy displays clear therapeutic responses, it is not effective in all cancer patients, indicating modulation by other factors. We applied cell surfa...
ORGANISM(S): Homo sapiens (Human) 
2026-01-16 | PXD064698 | Pride
Tspan4 Pd-l1 Melanoma Surface proximity biotinylation 
ProteomicsAllobaculum mucolyticum is a novel mucin degrader
The human gut microbiota plays a central role in intestinal health and disease. However, many of its bacterial constituents are functionally still largely unexplored. A crucial prerequisite for bacterial survival and proliferation is the creation and/or exploitation of an own niche. For many bacteri...
ORGANISM(S): Allobaculum sp. 
2021-09-22 | PXD024919 | Pride
Ibd Allobaculum mucolyticum Secretome 
ProteomicsA mass spectrometry survey of chromatin-associated proteins in pluripotency and early lineage commitment
Pluripotent Embryonic Stem Cells (ESCs) can be captured in vitro in different states, ranging from unrestricted ‘naïve’ to more developmentally constrained ‘primed’ pluripotency. Complexes involved in epigenetic regulation and key transcription factors have been shown to be involved in specifying th...
ORGANISM(S): Mus musculus (Mouse) 
2019-07-04 | PXD011782 | Pride
Differentiation Naïve pluripotency Lc-ms Primed pluripotency Mouse Chromatin 
ProteomicsQuantitative subcellular proteomics using SILAC reveals enhanced metabolic buffering in ground state pluripotency
The ground state of pluripotency is defined as a minimal unrestricted state as present in the Inner Cell Mass (ICM). Mouse embryonic stem cells (ESCs) grown in a defined serum-free medium with two kinase inhibitors (‘2i’) reflect this state, whereas ESCs grown in the presence of serum (‘serum’) shar...
ORGANISM(S): Mus musculus (Mouse) 
2018-11-07 | PXD009217 | Pride
Embryonic stem cells Naïve pluripotency Metabolism Silac 
ProteomicsTwo distinct functional axes of positive feedback-enforced PRC2 recruitment in mouse embryonic stem cells
Polycomb Repressive Complex 2 (PRC2) plays an essential role in development by catalysing trimethylation of histone H3 lysine 27 (H3K27me3), resulting in gene repression. PRC2 consists of two sub-complexes, PRC2.1 and PRC2.2, in which the PRC2 core associates with distinct ancillary subunits such as...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-07 | PXD014290 | Pride
Chromatin Prc2 Embryonic stem cells Polycomb 
ProteomicsTwo distinct functional axes of positive feedback-enforced PRC2 recruitment in mouse embryonic stem cells
Polycomb Repressive Complex 2 (PRC2) plays an essential role in development by catalysing trimethylation of histone H3 lysine 27 (H3K27me3), resulting in gene repression. PRC2 consists of two sub-complexes, PRC2.1 and PRC2.2, in which the PRC2 core associates with distinct ancillary subunits such as...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-22 | PXD020684 | Pride
Chromatin Prc2 Embryonic stem cells Polycomb 
ProteomicsIdiopathic focal segmental glomerulosclerosis plasmas increase lipid droplet formation and perilipin-2 expression in human podocytes
Background: Many patients with idiopathic focal segmental glomerulosclerosis (FSGS) develop recurrence of proteinuria after kidney transplantation. Several circulating permeability factors (CPFs) responsible for recurrence have been suggested, but there is no consensus about the identity of CPFs in ...
ORGANISM(S): Homo sapiens (Human) 
2022-12-22 | PXD028536 | Pride
Circulating permeability factor Podocytes Lipid droplets Perilipin-2 Idiopathic focal segmental glomerulosclerosis (fsgs) 
ProteomicsCell cycle phosphorylation dynamics in vivo reveals switch-like control of intrinsic disorder
Switch-like cyclin-dependent kinase (CDK)-1 activation is thought to underlie the abruptness of mitotic onset, but how CDKs can simultaneously phosphorylate many diverse substrates is unknown, and direct evidence for such phosphorylation dynamics in vivo is lacking. Here, we analysed protein phospho...
ORGANISM(S): Xenopus Laevis 
PXD026088 | panorama
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