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TranscriptomicsAmino acid deprivation due to overexpression of UCP1 in skeletal muscle: signalling via FGF-21
Recent studies on mouse and human skeletal muscle (SM) demonstrated the important link between mitochondrial function and the cellular metabolic adaptation. To identify key compensatory molecular mechanisms in response to chronic mitochondrial distress, we analyzed mice with ectopic SM respiratory u...
ORGANISM(S): Mus musculus 
2015-02-17 | E-GEOD-45991 | biostudies-arrayexpress
ProteomicsActivity-based protein profiling in human M2 macrophages using DHA-based photoaffinity probes
17-Hydroxydocosahexaenoic acid (17-HDHA), an oxidative metabolite of the fish oil constituent docosahexaenoic acid (DHA, 22:6 n-3), is a signaling lipid with anti-inflammatory properties. The molecular mechanisms underlying the biological effect of 17-HDHA are poorly understood. Here, we report the ...
ORGANISM(S): Homo sapiens (Human) 
2023-04-28 | PXD027600 | Pride
Human Abpp Photoaffinity Macrophage 
ProteomicsABPP using chemical proteomics in Alzheimer's Disease and Resilience
pulldown on enzymes targeted by serine hydrolase probes tetrahydrolipstatin-biotin and fluorophosphonate biotin probe in lysates from the frontal cortex of 36 patients (12 conrol, 12 Alzheimer's, 12 Resilient). below is the abstract: Alzheimer’s Disease (AD) is the most common form of dementia. Wh...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD057993 | Pride
Abpp Alzheimer's disease Serine hydrolases 
TranscriptomicsAmino acid deprivation due to overexpression of UCP1 in skeletal muscle: signalling via FGF-21
Recent studies on mouse and human skeletal muscle (SM) demonstrated the important link between mitochondrial function and the cellular metabolic adaptation. To identify key compensatory molecular mechanisms in response to chronic mitochondrial distress, we analyzed mice with ectopic SM respiratory u...
ORGANISM(S): Mus musculus 
2015-02-17 | GSE45991 | GEO
ProteomicsProfiling the anandamide reuptake inhibitor WOBE437
Anandamide, or N-arachidonoylethanolamine (AEA), is a signaling lipid that modulates neurotransmitter release via activation of the cannabinoid receptor type 1 (CB1R) in the brain. Termination of anandamide signaling is thought to be mediated via a facilitated cellular reuptake process utilizing an ...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-04 | PXD031488 | Pride
Abpp Photoaffinity Proteomics Endocannabinoid 
ProteomicsDiscovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice
N‑acylethanolamines (NAEs), which include the endocannabinoid anandamide, represent an important family of signaling lipids in the brain. The lack of chemical probes that modulate NAE biosynthesis in living systems hamper the understanding of the biological role of these lipids. Using a high-through...
ORGANISM(S): Homo sapiens (Human) 
2020-05-15 | PXD017586 | Pride
Lipids Drug discovery Endocannabinoids Chemical biology 
UnknownStructure-Activity Relationship Studies of Pyrimidine-4-Carboxamides as Inhibitors of N-Acylphosphatidylethanolamine Phospholipase D.
Not available
S-EPMC7816197 | biostudies-literature
UnknownNo Adverse Programming by Post-Weaning Dietary Fructose of Body Weight, Adiposity, Glucose Tolerance, or Metabolic Flexibility.
Not available
S-EPMC5814917 | biostudies-literature
ProteomicsEmploying Sterculic Acid–a naturally occurring 1, 2-cyclopropene fatty acid–for live-cell imaging of lipids by inverse electron-demand Diels-Alder reaction
To allow the study of unsaturated free fatty acids in live cells, we here report the use of sterculic acid, a 1,2-cyclopropene containing oleic acid analogue, as a bioorthogonal probe. We here show that this lipid can be readily taken up by dendritic cells without toxic side-effects, and that it can...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-28 | PXD033831 | Pride
Lipidation Ptm Bioorthogonal Sterculic Cyclopropene 
TranscriptomicsQuercetin decreases high-fat diet induced bodyweight gain and accumulation of hepatic and circulating lipids in mice.
Dietary flavonoids are supposed to be protective against cardiovascular diseases (CVD). Elevated circulating lipid levels and hepatic lipid accumulation are known risk factors for CVD. We investigated the effects and underlying molecular mechanisms of the flavonoid quercetin on hepatic lipid metabol...
ORGANISM(S): Mus musculus 
2014-10-14 | E-GEOD-51343 | biostudies-arrayexpress
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