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ProteomicsBistability in the Rac1, PAK and RhoA signalling network is a feature of cell motility.
Dynamic interactions between RhoA and Rac1, members of the Rho small GTPase family, play a vital role in the control of cell migration. Using predictive mathematical modelling and experimental validation in MDA-MB-231 mesenchymal breast cancer cells, we show that Rac1 and RhoA interactions via the P...
ORGANISM(S): Homo sapiens (Human) 
2016-12-23 | PXD003213 | Pride
Mathematical modelling Rhoa Cell motility Rac1 Bistable switches Pak inhibition 
ProteomicsHypoxia decreases the pathogenicity of Pseudomonas aeruginosa by reducing expression of multiple virulence factors.
Hypoxia is a feature of the microenvironment during P. aeruginosa infection in several disease states. We confirm that the pathogenicity of P. aeruginosa derived from sites of acute infection is higher than those derived from sites of chronic infection. Hypoxia attenuated the pathogenicity of acute ...
ORGANISM(S): Pseudomonas aeruginosa str. E2UoS 
2017-06-06 | PXD004421 | Pride
Hypoxia Pseudomonas aeruginosa 
ProteomicsBistability in the Rac1, PAK and RhoA signalling network is a feature of cell motility.
Dynamic interactions between RhoA and Rac1, members of the Rho small GTPase family, play a vital role in the control of cell migration. Using predictive mathematical modelling and experimental validation in MDA-MB-231 mesenchymal breast cancer cells, we show that Rac1 and RhoA interactions via the P...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080751 | MassIVE
ProteomicsHypomorphic mutations in PLAA cause an infantile neurodevelopmental syndrome by disrupting synaptic protein turnover through multivesicular body dysfunction
During endosomal trafficking, the ubiquitin-status of membrane-bound protein cargo determines whether it is recycling to the surface or trafficked through intermediate multivesicular bodies (MVBs) for lysosomal degradation. Neurons, particularly their synapses, are extremely sensitive to perturbatio...
ORGANISM(S): Mus musculus (Mouse) 
2018-07-11 | PXD003140 | Pride
Mouse cerebelluym 
ProteomicsAsparagine hydroxylation is likely to be a reversible post-translational modification
Amino acid hydroxylation is a common post-translational modification, which generally regulates protein interactions or adds a functional group that can be further modified. Such hydroxylation is currently considered irreversible, necessitating the degradation and re-synthesis of the entire protein ...
ORGANISM(S): Hordeum vulgare (Barley) 
2020-03-23 | PXD013116 | Pride
Lc-ms/ms Hydroxylation Hypoxia Ptm 
ProteomicsA novel transcriptional signalling pathway mediated by the trafficking protein Ambra1 via scaffolding Atf2 complexes
Previously, we reported that Ambra1 is a core component of a cytoplasmic trafficking network, acting as a spatial rheostat to control active Src and FAK levels in addition to its critical roles in autophagy during neurogenesis. Here we identify a novel nuclear scaffolding function for Ambra1 that co...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD018745 | Pride
Interaction proteomics Signalling 
ProteomicsA lysosomal delivery mechanism required for autophagosome degradation
Autophagy is a finely orchestrated process required for the lysosomal degradation of cytosolic components. The final degradation step is essential for clearing autophagic cargo and recycling macromolecules. We identified a highly conserved transmembrane protein named RNAseK as a novel regulator of a...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-05 | PXD042727 | Pride
Autophagy 
ProteomicsGrowth cone localization of the mRNA encoding a chromatin regulator modulates neurite outgrowth
Neurons exploit local mRNA translation and retrograde transport of transcription factors to regulate gene expression in response to signaling events at distal neuronal ends. Whether epigenetic factors could also be involved in such regulation is not known. We report that the mRNA encoding the HMGN5 ...
ORGANISM(S): Mus musculus (Mouse) 
2015-04-17 | PXD001070 | Pride
Hmgn5 Neuronal development Chromatin regulation 
ProteomicsA novel C1q domain-containing protein isolated from the bivalve mollusk Modiolus kurilensis recognizing glycans enriched with acidic galactans
C1q domain-containing (C1qDC) proteins are a group of biopolymers involved in immune response as pattern recognition receptors (PRRs) in a lectin manner identifying and binding carbohydrate components of pathogen-associated molecular patterns (PAMPs). In the current study, we present a new protein ...
ORGANISM(S): Modiolus kurilensis 
2022-02-17 | PXD027507 | Pride
De-novo sequencing Lc-ms/ms 
ProteomicsDnaaf4 and Dnaaf6 are required for assembly of ODAs and a subset of IDAs.
Axonemal dynein motors are large multisubunit complexes that drive ciliary movement. Cytoplasmic assembly of these motor complexes involves several co-chaperones, some of which are related to the R2TP co-chaperone complex. The different roles of these co-chaperones is not completely known. Two such ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-06-23 | PXD033608 | Pride
Cilia Drosphila 
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