Causal Relationship Between Blood Triglyceride Levels and Age Spots: A Mendelian Randomization Analysis.

ABSTRACT:

Objective

This study examined the association between blood triglyceride (TG) levels (TLIB) and age spots (AS).

Methods

We acquired data from the Mendelian randomization (MR) Base database and evaluated the causal association between TLIB and AS.

Results

From genome-wide association studies, we selected 33 single nucleotide polymorphisms (SNPs) that were significantly associated with TLIB and AS. The inverse variance-weighted (IVW) and weighted median estimation methods showed that TLIB had a protective effect on AS (IVW: β=-0.214, P=0.019, odds ratio [OR]=0.807, 95% confidence interval [CI]=0.674-0.966; weighted median: β=-0.277, P=0.032, OR=0.758, 95% CI=0.589-0.977). However, the MR-Egger analysis suggested no causal association (β=-0.234, P=0.

SUBMITTER: Liu H 

PROVIDER: S-EPMC10625373 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature