Causal association between air pollution and frailty: a Mendelian randomization study.

ABSTRACT:

Backgrounds

Frailty is a significant problem for older persons since it is linked to a number of unfavorable consequences. According to observational researches, air pollution may raise the risk of frailty. We investigated the causal association between frailty and air pollution (including PM_2.5, PM_2.5-10, PM₁₀, nitrogen dioxide, and nitrogen oxides) using Mendelian randomization approach.

Methods

We conducted MR analysis using extensive publically accessible GWAS (genome-wide association studies) summary data. The inverse variance weighted (IVW) method was employed as the primary analysis method. The weighted median model, MR-Egger, simple model, and weighted model approaches were chosen for quality control. The Cochran's Q test was utilized

SUBMITTER: Xiao H 

PROVIDER: S-EPMC10662305 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature