Development of 68Ga-Labeled Hepatitis E Virus Nanoparticles for Targeted Drug Delivery and Diagnostics with PET.
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ABSTRACT:
SUBMITTER: Lambidis E
PROVIDER: S-EPMC9346612 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
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Development of <sup>68</sup>Ga-Labeled Hepatitis E Virus Nanoparticles for Targeted Drug Delivery and Diagnostics with PET.
Lambidis Elisavet E Chen Chun-Chieh CC Baikoghli Mo M Imlimthan Surachet S Khng You Cheng YC Sarparanta Mirkka M Cheng R Holland RH Airaksinen Anu J AJ
Molecular pharmaceutics 20220720 8
Targeted delivery of diagnostics and therapeutics offers essential advantages over nontargeted systemic delivery. These include the reduction of toxicity, the ability to reach sites beyond biological barriers, and the delivery of higher cargo concentrations to diseased sites. Virus-like particles (VLPs) can efficiently be used for targeted delivery purposes. VLPs are derived from the coat proteins of viral capsids. They are self-assembled, biodegradable, and homogeneously distributed. In this st ...[more]
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