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ProteomicsArginine (di)methylated Human Leukocyte Antigen class I peptides are favorably presented by HLA-B*07
Specific alterations in protein post-translational modification (PTMs) are recognized hallmarks of diseases. These modifications potentially provide a unique disease-related source of Human Leukocyte Antigen (HLA) class I-presented peptide antigens that can elicit specific immune responses. Although...
ORGANISM(S): Homo sapiens (Human) 
2016-08-15 | PXD004233 | Pride
Methylation Dimethylation Ethcd Hla-class i 
ProteomicsIdentification of novel HLA class I-restricted hepatitis B virus peptides and their modulation by peptide editor TAPBPR
Hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma and infections remain a substantial global health problem for which no curative therapy exists. As cytotoxic CD8+ T lymphocytes are the principal effectors of natural HBV resolution, there is considerable interest in discoverin...
ORGANISM(S): Homo sapiens (Human) 
2026-07-15 | PXD078020 | Pride
Immunopeptidomics Hla Tapbpr Mhc 
ProteomicsThe HLA ligandome comprises a limited repertoire of O-GlcNAcylated antigens preferentially associated with HLA-B07:02
Mass-spectrometry based immunopeptidomics has provided unprecedented insights into antigen presentation, not only charting an enormous ligandome of self-antigens, but also cancer neo-antigens and peptide antigens harbouring post-translational modifications. Here we concentrate on the latter, focusin...
ORGANISM(S): Homo sapiens (Human) 
2021-12-03 | PXD028874 | Pride
O-glcnacylation Hla-b07 Mhc Hla class i Immunopeptidomics 
ProteomicsUnsupervised mining of HLA-I peptidomes reveals unsuspected false positives and new binding motifs
Modern antigen vaccine designs and studies of human leukocyte antigen (HLA)-mediated immune responses rely heavily on the knowledge of HLA allele-specific binding motifs and computational prediction of antigen-HLA binding affinity. Breakthroughs in HLA peptidomics have considerably expanded the data...
ORGANISM(S): Homo sapiens (Human) 
2021-09-17 | PXD028088 | Pride
Smsnet Peptidome Hla-i 
GenomicsHLA Class I submissions 240531
HLA class I submissions 240531
PRJEB76242 | ENA
ProteomicsIntra-patient clonal diversity in HLA class I peptide ligand presentation
Tumor heterogeneity results from clonal diversity and evolutionary selection, and is a major cause of therapeutic resistance. Immunotherapy may exploit alternative vulnerabilities of drug resistant cells, and tumor-specific HLA peptide ligands on the cell surface are promising leads to invoke such t...
ORGANISM(S): Homo sapiens (Human) 
2020-10-26 | PXD016582 | Pride
Hla class i peptide ligands  colorectal cancer  tumor heterogeneity  patient-derived organoids  mass spectrometry  affinity proteomics 
ProteomicsHLA class I ligandome of colon cancer tissues for neoantigen identification
MS data of HLA class I ligandome of human colon cancer tissues
ORGANISM(S): Homo Sapiens (human) 
2021-07-26 | PXD026573 | JPOST Repository
GenomicsHLA Class I/II submissions 240607
HLA class I/II submissions 240607
PRJEB76430 | ENA
ProteomicsTemperature induced change of the HLA ligandome
Temperature induced change of the HLA ligandome and proteome in B-cells
ORGANISM(S): Homo sapiens (Human) 
2021-05-07 | PXD022930 | Pride
Hla class ii ligandome Hla class i ligandome Immunopeptidome Proteome Lc-ms/ms 
ProteomicsMass spectrometric profiling of HLA-B44 peptidomes provides evidence for tapasin-mediated tryptophan editing
The extreme polymorphisms of human leukocyte antigen (HLA) class I proteins result in structural variations in their peptide binding sites to achieve diversity in antigen presentation. External factors could independently constrict or alter HLA class I peptide repertoires. Such effects of the assemb...
ORGANISM(S): Homo sapiens (Human) 
2024-07-15 | PXD046825 | Pride
Hla-b*44:02 Hla-b*44:05 Tapasin Peptide binding affinity Tryptophan Peptide loading complex Hla class i Immunopeptidome Half-life Mhc class i 
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