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TranscriptomicsNoncoding RNA expression in myocardium from infants with tetralogy of Fallot [miRNA profiling]
This is the first report characterizing noncoding RNA expression in a congenital heart defect. The striking shift in expression of noncoding RNAs reflects a fundamental change in cell biology, likely impacting expression, transcript splicing and translation of developmentally important genes and pos...
ORGANISM(S): Homo sapiens 
2012-07-11 | E-GEOD-35490 | biostudies-arrayexpress
TranscriptomicsNoncoding RNA expression in myocardium from infants with tetralogy of Fallot
This SuperSeries is composed of the following subset Series: GSE35490: Noncoding RNA expression in myocardium from infants with tetralogy of Fallot [miRNA profiling] GSE35776: Noncoding RNA expression in myocardium from infants with tetralogy of Fallot [mRNA profiling] Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-07-11 | E-GEOD-35781 | biostudies-arrayexpress
TranscriptomicsGene profiling of Hand2 target genes and transcriptional regulation of Hand2 expression in the postnatal myocardium
In humans, cardiac hypertrophy is the principal risk factor for the development of overt heart failure and sudden cardiac death from lethal arrhythmias. Although aberrant reactivation of fetal² gene programs is intricately linked to maladaptive hypertrophy of postnatal cardiomyocytes, loss of cardi...
ORGANISM(S): Mus musculus 
2013-11-15 | E-MTAB-1821 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human right ventricular samples acquired during cardiac surgery
Right ventricular samples were serially acquired during surgical repair of ventricular septal defect. Expression profiling revealed three patterns of gene expression: (1) increased expression above control levels within one hour of cardioplegic arrest, with further amplification during early reperfu...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6381 | biostudies-arrayexpress
TranscriptomicsMyocardial transcriptome analysis of human arrhythmogenic right ventricular cardiomyopathy (ARVC)
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiomyopathy primarily of the right ventricle characterized through fibrofatty replacement of cardiomyocytes. The genetic etiology in ARVC patients is most commonly caused by dominant inheritance and high genetic heterogeneity....
ORGANISM(S): Homo sapiens 
2011-11-30 | E-GEOD-29819 | biostudies-arrayexpress
ProteomicsUnveiling human proteome signatures of heart failure with preserved ejection
Heart Failure with preserved ejection fraction (HFpEF) is a major health challenge affecting millions of people worldwide. Moreover, this disease presents multiple etiologies and associated comorbidities, leading to difficulties in diagnosis and limited therapeutic options. HFpEF underlying cellular...
ORGANISM(S): Homo sapiens (Human) 
2022-11-29 | PXD033876 | Pride
Heart failure with preserved ejection fraction  human myocardium ventricular samples  untargeted proteomics 
ProteomicsBioinformatic analysis of membrane and associated proteins in murine cardiomyocytes and human myocardium
In the current study we examined several proteomic- and RNA-Seq-based datasets of cardiac-enriched, cell-surface and membrane-associated proteins in human fetal and mouse neonatal ventricular cardiomyocytes. By integrating available microarray and tissue expression profiles along with MGI phenotypic...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2020-11-17 | PXD017732 | Pride
Bioinformatics Therapeutics Cardiomyocytes Membrane proteins Heart disease 
ProteomicsVentricle-specific myocardial protein and metabolite characterisation in healthy humans, with differential regulation in end-stage cardiomyopathies
The left and right ventricles of the human heart are functionally and developmentally distinct such that genetic or acquired insults can cause dysfunction in one or both ventricles resulting in heart failure. First, we performed unbiased quantitative mass spectrometry on the myocardium of 25-27 pre-...
ORGANISM(S): Homo sapiens (Human) 
2024-11-06 | PXD042155 | Pride
Human Ventricle Glutamine Ischaemia Heart Cardiomyopathy 
TranscriptomicsGene expression analysis in non-failing and failing myocardium pre and post pulsatile and non-pulsatile VAD support
Mechanical unloading by ventricular assist devices (VAD) leads to significant gene-expression changes often summarized as reverse remodeling. However, little is known on individual transcriptome changes during VAD-support and its relationship to non-failing hearts (NF). In addition no data are avail...
ORGANISM(S): Homo sapiens 
2010-07-29 | E-GEOD-21610 | biostudies-arrayexpress
ProteomicsProteomic analysis of right-ventricular dysfunction (RVD) in patients with advanced chronic heart failure.
This research aimed to identify protein biomarkers of right ventricular dysfunction in patients with advanced heart failure with reduced ejection fraction (HFrEF). Samples of myocardium from both, right and left ventricles (RV, LV) were obtained from 10 HFrEF patients with right ventricular dysfunct...
ORGANISM(S): Homo sapiens (Human) 
2025-02-11 | PXD043768 | Pride
Myocardium Right ventricular dysfunction Lfq Triton x-100 Chronic heart failure Biomarkers Rvd 
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