Sort   by:  
 Page size 
ProteomicsCancer Cell Extravasation Requires iPlectin Mediated Choreography of MT1-MMP at Invadopodia
Cancer cell extravasation is a key step of the metastatic cascade and an attractive therapeutic opportunity. Early steps in cancer cell extravasation require formation of tentacle-like protrusions called invadopodia that physically breach the endothelial barrier and degrade extracellular matrix (EC...
ORGANISM(S): Homo sapiens (Human) 
2025-03-28 | PXD039276 | Pride
Invadopodia Cancer Protein-protein interactions 
ProteomicsInvadopodia small extracellular vesicles glioblastoma
The therapeutic efficacy of radiotherapy and chemotherapy with temozolomide (TMZ) for glioblastoma (GBM) is currently limited by the augmented invasive abilities of GBM cells that survive treatment, however the underlying mechanisms remain poorly understood. Due to their ability of transporting onco...
ORGANISM(S): Homo sapiens (Human) 
2023-07-24 | PXD031077 | Pride
Therapeutic Glioblastoma Cancer Small extracellular vesicles Invadopodia Radiotherapy 
ProteomicsA proximity-labeling proteomic approach to investigate invadopodia molecular landscape in breast cancer cells
Invadopodia constitute a specialized machinery required for invasive tumor cells to travel through basement membranes and the interstitial matrix, and thus represent a key feature of metastatic cells. Therefore a better understanding of invadopodia biology and characteristics might permit the identi...
ORGANISM(S): Homo sapiens (Human) 
2020-04-24 | PXD015847 | Pride
Actin cytoskeleton Cancer invasion Tks5/sh3pxd2a 
ProteomicsSerine-threonine kinase TAO3 mediated trafficking of endosomes containing the invadopodia scaffold TKS5-alpha promotes cancer invasion and tumor growth
Invadopodia are actin-based proteolytic membrane protrusions required for invasive behavior and tumor growth. In this study, we used our high-content screening assay to identify kinases whose activity impacts invadopodia formation. Among the top hits selected for further analysis was TAO3, a STE20-l...
ORGANISM(S): Homo sapiens (Human) 
2021-01-29 | PXD023867 | Pride
Tks5-alpha Taok3 Tao3 Tmt data Invadopodia Endosomes Phosphoproteomics Ptm quantitation Orbitrap fusion 
UnknownDynamic membrane remodeling at invadopodia differentiates invadopodia from podosomes.
Not available
S-EPMC3153956 | biostudies-literature
UnknownExtracellular matrix rigidity promotes invadopodia activity.
Not available
S-EPMC2555969 | biostudies-literature
ProteomicsE-cadherin: Unexpected actor of invadopodia formation in pancreatic cancer
E-cadherin is known as an epithelial marker often associated with tumour suppressive function. However, several studies revealed that some tumours cells, such as pancreatic cancer cells, with epithelial traits and high E-cadherin expression can undergo metastasis and form secondary tumours. These ob...
ORGANISM(S): Homo sapiens (Human) 
2025-05-14 | PXD021795 | Pride
Human Lc-msms E-cadherin Cell invasion Invadopodia Pancreatic cancer 
UnknownECM Cross-Linking Regulates Invadopodia Dynamics.
Not available
S-EPMC5883616 | biostudies-literature
UnknownARHGAP17 regulates the spatiotemporal activity of Cdc42 at invadopodia.
Not available
S-EPMC9794838 | biostudies-literature
UnknownAdhesion rings surround invadopodia and promote maturation.
Not available
S-EPMC3507228 | biostudies-literature
Sort   by:  
 Page size