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MetabolomicsMulti‐omics identify xanthine as a pro‐survival metabolite for nematodes with mitochondrial dysfunction
Aberrant mitochondrial function contributes to the pathogenesis of various metabolic and chronic disorders. Inhibition of insulin/IGF-1 signaling (IIS) represents a promising avenue for the treatment of mitochondrial diseases, although many of the molecular mechanisms underlying this beneficial effe...
2019-02-28 | MTBLS794 | MetaboLights
ProteomicsMitochondrial protein interaction landscape of SS-31
SS-31 is a synthetic peptide that improves mitochondrial function and is currently undergoing clinical trials for treatments of heart failure, primary mitochondrial myopathy, and other mitochondrial diseases. SS-31 interacts with cardiolipin which is abundant in the inner mitochondrial membrane, but...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-12 | PXD019484 | Pride
Cross-linking mass spectometry Mitochondria Ss-31 Mouse Elamipretide 
UnknownMitochondrial protein interaction landscape of SS-31.
Not available
S-EPMC7334473 | biostudies-literature
TranscriptomicsGlobal analysis of the RNA-protein interaction and RNA secondary structure landscapes of the Arabidopsis nucleus
Post-transcriptional regulation in eukaryotes requires cis- and trans-acting features and factors including RNA secondary structure, and RNA-binding proteins (RBPs). However, a comprehensive view of the structural and RBP interaction landscape of RNAs in the nucleus has yet to be compiled for any or...
ORGANISM(S): Arabidopsis thaliana 
2014-12-16 | E-GEOD-58974 | biostudies-arrayexpress
TranscriptomicsRNA-immunoprecipitation of mTRAN1-GFP
mTRAN proteins are components of the plant mitochondrial small subunits, thought to bind the mRNA 5' regions to initiate translation. This experiment was designed to identify the mTRAN1 binding regions on the plant mitochondrial mRNAs
ORGANISM(S): Arabidopsis thaliana 
2023-09-01 | E-MTAB-13060 | biostudies-arrayexpress
UnknownNovel interaction interfaces mediate the interaction between the NEIL1 DNA glycosylase and mitochondrial transcription factor A.
Not available
S-EPMC9354671 | biostudies-literature
TranscriptomicsPervasive and dynamic protein binding sites of the mRNA transcriptome in Saccharomyces cerevisiae
Protein-RNA interactions are integral components of nearly every aspect of biology including regulation of gene expression, assembly of cellular architectures, and pathogenesis of human diseases. However, studies in the past few decades have only uncovered a small fraction of the vast landscape of t...
ORGANISM(S): Saccharomyces cerevisiae 
2013-01-29 | E-GEOD-43747 | biostudies-arrayexpress
ProteomicsRelaxin-2: shaping the proteomic landscape of skeletal muscle physiology, glucose trafficking, and mitochondrial function in rat.
Relaxin-2 is a hormone with robust beneficial effects on the heart and blood vessels and with a potential therapeutic efficacy in cardiovascular (CV) disease. Considering the interorgan communication between skeletal muscle and heart, and the relation between muscle quality/composition and CV events...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-09-21 | PXD078619 | Pride
Serelaxin Phosphoproteome Mitochondrial respiration Metabolism. Skeletal muscle Relaxin-2 Myogenesis Proteome 
ProteomicsA Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Molecular Determinants in Redox Homeostasis and NF-κB Signaling
Mitochondrial protein (MP) dysfunction has been linked to neurodegenerative disorders (NDs), however, the discovery of molecular mechanisms underlying NDs has been impeded by the limited characterization of interactions governing MP function. Here, using 109 affinity-purified mitochondrial fractions...
ORGANISM(S): Homo sapiens (Human) 
2017-12-05 | PXD006690 | Pride
Parkinson's disease Autism Mitochondria Nf-kb signaling Mitochondrial proteins Neurodegeneration Protein-protein interactions Proteomics 
TranscriptomicsRibo-seq of Arabidopsis mTRAN double mutants
mTRAN proteins are are plant specific-components of the mitoribosome. To asses of loss-of-function mtran1 mtran2 double mutants show decreased translation rates, we performed ribosome footprinting coupled to RNA-seq (Ribo-seq).
ORGANISM(S): Arabidopsis thaliana 
2023-09-01 | E-MTAB-13059 | biostudies-arrayexpress
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