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ProteomicsmPFC Synaptosome Proteomics Reveals Novel Pathways and Muscarinic Receptor Changes in a Learned Helplessness Mouse Model
Stressful events are a leading factor in development of depression. The medial prefrontal cortex (mPFC) is strongly associated with depression etiology and exposure to uncontrollable stressors results in synaptic dysfunction and loss. Learned helplessness is a behavioral paradigm that measures effec...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-20 | PXD073765 | Pride
Mpfc Acetylcholine Major depressive disorder Stress models Learned helplessness Muscarinic receptors Proteomics 
GenomicsThe M3 Muscarinic Acetylcholine Receptor Promotes Epidermal Differentiation
The M3 Muscarinic Acetylcholine Receptor Promotes Epidermal Differentiation
PRJNA833409 | ENA
ProteomicsMolecular mechanism of muscarinic acetylcholine receptor M3 interaction with Gq
Muscarinic acetylcholine receptor M3 (M3) and its downstream effector Gq/11 are critical drug development targets given their involvement in numerous physiological processes and diseases. Although a cryo-electron microscopy study previously defined the structure of the M3-miniGq complex, the lack of...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD042562 | Pride
Hdx-ms M3 G protein Gq Gpcr 
ProteomicsSlowing prion disease via M1 muscarinic receptors is associated with reduced neuroinflammation and down-regulation of neurodegenerative disease markers
Currently there are no treatments that can slow or halt the progression of dementia’s including Alzheimer’s disease. Here we investigate the possibility that activation of the M1-muscarinic receptor (M1-receptor), which is highly expressed in the brain and that shows pro-cognitive properties, might ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-14 | PXD025561 | Pride
G protein-coupled receptor Alzheimer’s disease Neuroinflammation Warwick_rtp Positive allosteric modulators Transcriptomic Prion disease Proteomic Neurodegeneration Neurodegenerative disease M1 muscarinic acetylcholine receptor 
TranscriptomicsTranscription profiling of rat heart tissue from animals aged 4 and 22 months
Myocardial aging leads to a reduction of beta-adrenergic receptor-induced metabolic and contractile responsiveness. We hypothesize that a change in the patterns of gene expression is important in these age-related events. To test this, hearts were harvested from young and aged male rats (3-4 and 20-...
ORGANISM(S): Rattus norvegicus 
2007-10-10 | E-GEOD-421 | biostudies-arrayexpress
GenomicsThe effect of deletion of muscarinic acetylcholine receptor 4 in Math1 expressing cells in the small intestine
The effect of deletion of muscarinic acetylcholine receptor 4 in Math1 expressing cells in the small intestine
PRJNA1123146 | ENA
ProteomicsLow intrinsic agonism and balanced pathway modulation distinguish an M1 muscarinic receptor positive allosteric modulator lacking cholinergic adverse effects
Positive allosteric modulators (PAMs) of the M1 muscarinic acetylcholine receptor (mAChR) have progressed into clinical trials for cognitive disorders, such as Alzheimer’s disease and schizophrenia. This work provides a mechanistic framework for differentiating M1 PAM pharmacology beyond intrinsic a...
ORGANISM(S): Homo sapiens (Human) 
2026-07-06 | PXD074843 | Pride
Signalling pathways Schizophrenia Cognition Alzheimer's disease M1 muscarinic acetylcholine receptors Allosteric modulation Biased allosterism 
UnknownStructure of the human M2 muscarinic acetylcholine receptor bound to an antagonist.
Not available
S-EPMC3345277 | biostudies-literature
GenomicsTranscriptional and functional profiles of muscarinic cholinergic receptor-expressing neurons in the primate prefrontal cortex
Transcriptional and functional profiles of muscarinic cholinergic receptor-expressing neurons in the primate prefrontal cortex
PRJNA1257933 | ENA
TranscriptomicsThe effect of deletion of muscarinic acetylcholine receptor 4 in Math1 expressing cells in the small intestine
The muscarinic acetylcholine receptor 4 was inducibly deleted in Math1 expressing lineages and alterations in gene expression evaluated by bulk RNA sequencing
ORGANISM(S): Mus musculus 
2025-06-01 | GSE269646 | GEO
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