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ProteomicsThe temporal profile of activity-dependent presynaptic phospho-signalling reveals long lasting patterns of post-stimulus regulation
Depolarization of presynaptic terminals stimulates calcium influx, which evokes neurotransmitter release and activates phosphorylation-based signalling. Here, we present the first global temporal profile of presynaptic activity-dependent phospho-signalling, which includes two KCl stimulation levels ...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-01-28 | PXD010007 | Pride
Neuron Phosphorylation Rat Phosphatase Signalling Synaptosome Presynaptic Depolarization Kinase Post-stimulus Pp1 
UnknownPresenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.
Not available
S-EPMC3773738 | biostudies-literature
ProteomicsProteomics of the temporal cortex in Semantic Dementia reveals brain-region specific molecular pathology and regulation of the TDP-43-ANXA11 interactome
Semantic dementia (SD) is a clinical subtype of frontotemporal dementia characterized by impaired word comprehension and semantic memory, and occurs nearly always sporadically. Neuroimaging typically reveals asymmetric, predominantly left-sided, atrophy of the anterior temporal pole, anterior fusifo...
ORGANISM(S): Homo sapiens (Human) 
2026-01-16 | PXD062722 | Pride
Semantic dementia  ftld-tdp type c  temporal cortex  quantitative proteomics  rnp complex  presynaptic regulation calcium levels  tardbp-anxa11 interactome  immunohistochemistry 
UnknownThe temporal profile of activity-dependent presynaptic phospho-signalling reveals long-lasting patterns of poststimulus regulation.
Not available
S-EPMC6415872 | biostudies-literature
UnknownA Presynaptic Glutamate Receptor Subunit Confers Robustness to Neurotransmission and Homeostatic Potentiation.
Not available
S-EPMC5538789 | biostudies-literature
UnknownPresynaptic residual calcium and synaptic facilitation at hippocampal synapses of mice with altered expression of SNAP-25.
Not available
S-EPMC3246534 | biostudies-literature
ProteomicsChaperone-mediated autophagy sex-specifically regulates neuronal activity by remodeling the synaptic proteome
Chaperone-mediated autophagy (CMA) declines in aging and neurodegenerative diseases. CMA loss in neurons leads to neurodegeneration and behavioral changes in mice, but the role of CMA in neuronal physiology is largely unknown. Here, we show that CMA deficiency causes neuronal hyperactivity, disrupte...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-04 | PXD057545 | Pride
Aging  alzheimer’s disease  autophagy  hyperexcitability  lysosomes  neurodegeneration  sexual dimorphism  synaptic plasticity 
UnknownHomeostatic Depression Shows Heightened Sensitivity to Synaptic Calcium.
Not available
S-EPMC8139420 | biostudies-literature
UnknownA Glutamatergic Spine Model to Enable Multi-Scale Modeling of Nonlinear Calcium Dynamics.
Not available
S-EPMC6072875 | biostudies-literature
UnknownPresynaptic neurons self-tune by inversely coupling neurotransmitter release with the abundance of CaV2 voltage-gated Ca<sup>2+</sup> channels.
Not available
S-EPMC11363341 | biostudies-literature
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