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ProteomicsPROTEOMIC ANALYSIS OF THE UMBILICAL CORD IN FETAL GROWTH RESTRICTION AND PREECLAMPSIA
Fetal growth restriction (FGR) is associated with adverse perinatal outcomes. Pre-eclampsia (PreE) increases the associated perinatal morbidity and mortality. The structure of the umbilical cord in the setting of FGR and PreE has yet to be determined. This study aimed to examine chan...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-03-15 | MSV000087051 | MassIVE
ProteomicsExploiting trogocytosis by Immunopeptidomics to profile tumor associated antigens (TAA) actively targeted by tumor specific T cells in leukemia.
We employed PeptiCHIP Immunopeptidomics to profile tumor associated antigens (TAA) actively targeted by tumor specific T cells by exploiting the trogocytosis effect, whereby antigen presenting cells (APCs) nibble portions of the cognate T cell containing the TCR. The antigen presenting cells were th...
ORGANISM(S): Homo sapiens (Human) 
2023-09-07 | PXD035344 | Pride
T cell Leukemia Peptichip Trogocytosis Taa Ligandomics Tcr Hla-i Human Mhc-i Immunopeptidomics 
UnknownOptimized Time-Segmented Acquisition Expands Peptide and Protein Identification in TIMS-TOF Pro Mass Spectrometry.
Not available
S-EPMC11811991 | biostudies-literature
ProteomicsImmunopeptidomics of malignant mesothelioma to identify target antigens for T cell Immunotherapy
Immunoaffinity purification was performed on human mesothelioma cell lines NCI-H2452, NCI-H28, MSTO-211H and JL1, on murine mesothelioma cell line AB12, as well as on mesothelioma samples from two patients (including tumor and benign tissues). Thereafter Immunopeptidomics by Mass Spectrometry on a T...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-09-08 | PXD038273 | Pride
Jl1 H28 Msto211h Ab12 Ligandome Malignant pleural mesothelioma Cell lines Immunopeptidome Ligandomics Immunopeptidomics H2452 Cancer 
ProteomicsInvestigation of hepatic stellate cell proteomics during activa-tion with fetal bovine serum
Hepatic stellate cells (HSCs) are the major driving factor in liver fibrosis. Upon liver inflammation caused by alcohol abuse and/or a fatty liver, HSCs transform from a quiescent- into a proliferating, fibrotic phenotype. We study this transformation termed “activation”, using state of the art TIMS...
ORGANISM(S): Homo sapiens (Human) 
2022-02-14 | PXD029121 | Pride
Human Proteomics Activation Fibrosis Liver Hepatic stellate cells 
ProteomicsAn N-acetyltransferase required for N-terminal protein acetylation and virulence in Mycobacterium marinum
Raw and processed data in support of Collars et al., MS-MS/MS files used for manuscript TIMS-TOF Pro acquisition, IAA treated, trypsin digest.
ORGANISM(S): Mycobacterium Marinum (ncbitaxon:1781) 
2023-03-08 | MSV000091442 | MassIVE
ProteomicsOptimized Time-segment Acquisition Expands Peptide and Protein Identification in TIMS-TOF Pro Mass Spectrometry
We introduce a novel approach, termed time-segment acquisition (Seg), to enhance the identification of peptides and proteins in trapped ion mobility spectrometry (TIMS)-Time of flight (TOF) mass spectrometry. Our method exploits the positive correlation between ion mobility values and liquid chromat...
ORGANISM(S): Homo sapiens (Human) 
2024-12-22 | PXD051790 | Pride
Phosphoproteomics Timstof Ion mobility ms Tims Proteomics 
ProteomicsComparison of serum-free cultivated HepG2 cells with cells cultivated under FBS containing conditions using proteomic analysis
With an increasing focus in science, politics and society on animal welfare, human in vitro systems are gaining particular interest as potential replacement tools for animal experimentation. However, animal components are still commonly used in cell culture models, thereby compromising the true pote...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD056319 | Pride
Human Hepg2 cells Fbs Serum-free 
UnknownSingle ion mobility monitoring (SIM2) stitching method for high-throughput and high ion mobility resolution chiral analysis.
Not available
S-EPMC11294385 | biostudies-literature
ProteomicsAcute stress induces long-term metabolic, functional and structural remodeling of the heart
Takotsubo syndrome is a stress-induced cardiomyopathy with symptoms comparable to those of acute coronary syndrome but without coronary obstruction. Initially considered spontaneously reversible, the reversibility of takotsubo was challenged by epidemiological studies showing high morbi-mortality in...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-28 | PXD032667 | Pride
Tims tof pro Mouse heart takotsubo model Label-free quantification Stress-induced cardiomyopathy 
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