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ProteomicsComparative Two-Dimensional Polyacrylamide Gel Electrophoresis (2D-PAGE) of Human Milk to Identify Dysregulated Proteins in Breast Cancer
Breast Cancer (BC) remains a major cause of mortality, and early detection is considered important for reducing BC-associated deaths. Early detection of BC is challenging in young women, due to the limitations of mammography on the dense breast tissue of young women. We recently reported results of ...
ORGANISM(S): Homo sapiens (Human) 
2018-06-25 | PXD009860 | Pride
Mass spectrometry Breast cancer Breast milk 2d-page Proteomics Biomarkers 
ProteomicsSecretion of sonic hedgehog - The goal is to identify the proteins implicated in the secretion of sonic hedehog.
The goal is to identify the proteins implicated in the secretion of sonic hedehog.
ORGANISM(S): Homo sapiens (Human) 
2018-07-26 | PXD007990 | Pride
Nano-lc-ms/ms 1d sds-page stacking gel 
ProteomicsMetaproteome of chicken gastrointestinal tract microbiota
The chicken gastrointestinal tract (GIT) harbours a complex microbial community, involved in several physiological processes such as host immunomodulation and feed digestion. Other studies were already performed to define the chicken gut metagenome and its fecal metaproteome. For the first time, the...
ORGANISM(S): Bacteria 
2016-10-06 | PXD003805 | Pride
Microbiota Metaproteome 
ProteomicsSequential Window Acquisition of All Theoretical Mass Spectra (SWATH-MS) as an emerging proteomics approach for the discovery of dark-cutting beef biomarkers
Recent advances in “omics” technologies have opened the possibilities to discover novel biomarkers of meat quality, including the early detection of quality defects such as dark-cutting beef, also known as DFD (dark, firm, and dry) beef characterized by a high ultimate pH. The available studies char...
ORGANISM(S): Bos taurus (Bovine) 
2025-07-31 | PXD059876 | Pride
Beef quality defects  biological mechanisms  dark-cutting  protein biomarkers  proteome  shotgun proteomics. 
ProteomicsStructure and proteomics on centrosome from differentiated and quiescent cells: the thymocyte case
We have applied cryo-tomography and proteomics analyses to centrosomes isolated from young lamb thymus– a convenient source of quiescent and differentiated cells. Those analyses have allow us to better depict the protein organization joining the two centrioles in such a cellular system, in the form...
ORGANISM(S): Ovis aries 
2019-11-08 | PXD003928 | Pride
Cryo-tomography Centriolar disengagement Cohesin Proteomics Centrosome 
ProteomicsIPD3, a transcription factor necessary to establish arbuscular mycorrhizal symbiosis affects immunity and metabolism of non-host Arabidopsis 65 million years after its evolutionary loss
The goal of this study was to detect and quantify the presence of transgenic proteins in transformed A. thaliana plants and overall gene expression responses to presence of IPD3. Experimental plants were transformed with 3 versions of the gene Interacting Protein of DMI3 (IPD3), a transcription fact...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-02-20 | PXD040665 | Pride
Symbiosis Immunity Transformed plant Mycorrhizae Defense Transgenic proteins 
ProteomicsCysteine-directed isobaric labeling combined with GeLC-FAIMS MS for quantitative top-down proteomics
The quantification of proteoforms, i.e., all molecular forms in which proteins can be present, by top-down proteomics provides essential insights into biological processes at the molecular level. Isobaric labeling-based quantification strategies are suitable for multi-dimensional separation strategi...
ORGANISM(S): Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2025-05-07 | PXD055510 | Pride
Top-down proteomics  tmt labeling  quantitative proteomics  faims  gelc  peppi 
ProteomicsEnzyme adaptation to habitat thermal legacy shapes the thermal plasticity of marine microbiomes
Microbial communities respond to temperature with physiological adaptation and compositional turnover. Whether thermal selection of enzymes explains marine microbiome plasticity in response to temperature remains unresolved. By quantifying the thermal behaviour of seven functionally-independent enzy...
ORGANISM(S): Eubacteriales 
2023-02-07 | PXD039714 | Pride
Microbial physiology Climate changes Enzymatic activity Temperature variability Thermal response Marine bacteria 
ProteomicsPersulfidated subproteome reveals the regulation of protein function by hydrogen sulfide in diverse biological processes and nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase in plants.
Hydrogen sulfide-mediated signaling pathways regulates many physiological andpathophysiological processes in mammalian and plant systems. The molecular mechanism bywhich hydrogen sulfide exerts its action involves the oxidative post-translational modificationof cysteine residues to form a persulfida...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2017-10-27 | PXD005168 | Pride
Arabidopsis Hydrogen sulfide Gapdh Postranslational modification Nuclear localization S-sulfhydration 
ProteomicsComparative proteomic analysis of gonadal tissue in Solea senegalensis reveals reproductive deregulation associated with F1 individuals
Reproductive dysfunction in captive-bred Senegalese sole (Solea senegalensis) limits the consolidation of its aquaculture production, particularly due to reduced fertility and poor sperm quality in F1 males. To elucidate the molecular mechanisms underlying this problem, a quantitative proteomic anal...
ORGANISM(S): Solea senegalensis 
2026-08-24 | PXD071796 | Pride
Solea senegalensis  gonadal tissue  proteomic analysis  reproductive dysfunction. 
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