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TranscriptomicsRNA-seq of achilles tendon from young and old donors to study age-related changes in tendon
Tendon from young and old donors was used for RNA-Seq analysis. The aim of the study was to identify differentially expressed tendon transcripts in ageing in order to to characterize molecular mechanisms associated with age-related changes in tendon.
ORGANISM(S): Homo sapiens 
2015-04-01 | E-MTAB-2449 | biostudies-arrayexpress
ProteomicsGrafting induced pluripotent stem cells-derived tenocytes contribute to recovery of motor function after Achilles tendon rupture in rat
Self-renewal of tendons is rare since the vascular formation inside is extremely poor, thus reconstructive surgery using autologous tendons has been often taken place in the case of severe injury. However, the rate of re-injury after surgery is relatively high, and collection of autologous tendons l...
ORGANISM(S): Homo Sapiens (human) 
PXD020887 | JPOST Repository
TranscriptomicsHuman amniotic stem cells transcriptome is affected after xenotransplantation in a sheep achilles tendon defect model.
Amniotic derived cells are ideal seed cells for regenerative medicine protocols since they conjugate a remarkable plasticity to safety properties. This study investigated the role exerted by human amniotic cells during the process of tendon healing. In particular, in the present research it has been...
ORGANISM(S): Homo sapiens 
2014-06-30 | E-GEOD-53594 | biostudies-arrayexpress
ProteomicsStructure-function Relationships in Human Tendons: Interfascicular Matrix Specialisation in the Achilles Tendon C4PR_LIV
Tendon is a highly aligned connective tissue, in which the macro-structure consists of collagen-rich fascicles surrounded by interfascicular matrix (IFM). In a series of recent studies in equine tissue, we have demonstrated specialisation of tendon composition, structure and mechanics to achieve the...
ORGANISM(S): Homo sapiens (Human) 
2020-11-11 | PXD018212 | Pride
Structure-function Fascicles  interfascicularmatrix  mechanical testing  mass spectrometry  ageing 
ProteomicsiTRAQ-based proteomics reveals potential markers and treatment pathways for acute Achilles tendon rupture
We used the coupled isobaric tag for relative and absolute quantitation-liquid chromatography-electrospray ionization-tandem mass spectrometry approach to examine protein expression in acute Achilles tendon rupture patients.
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD046451 | Pride
Acute achilles tendon rupture Proteomics Itraq Biomarker Protein–protein interaction network 
TranscriptomicsExpression data from rat Achilles tendon-derived stem cells during development
We have compared the gene expression profile of rat Achilles tendon-derived stem cells in post-natal tendon development. Rat tendon stem/progenitor cells (TSPCs) were isolated at different stages of post-natal development: TSPCs-1d, TSPCs-7d and TSPCs-56d. TSPCs at different post-natal development s...
ORGANISM(S): Rattus norvegicus 
2015-07-10 | E-GEOD-68485 | biostudies-arrayexpress
ProteomicsUsing Quantitative Proteomic Assessments and their Association with Long Term Healing Outcomes
Healing after Achilles tendon rupture (ATR) is protracted with high individual variation and unsatisfactory outcome. Biomarkers prognostic of healing are unknown while physical and mechanical factors are used for predicting long-term healing outcomes in clinics today. The present study was designed ...
ORGANISM(S): Homo sapiens (Human) 
2022-05-25 | PXD029202 | Pride
Outcome Proteomics Mass spectrometry Healing Achilles tendon rupture Biomarkers 
GenomicsHuman Achilles tendon spatial transcriptomics
Human Achilles tendon spatial transcriptomics
PRJNA1397199 | ENA
ProteomicsLabel-free quantitative proteomics of Achilles and tail tendon fascicles from WT and VHL KO mice
Tendon integrity depends on controlled extracellular matrix production and adaptation to mechanical load. Dysregulated hypoxia-inducible factor 1α (HIF1α) signaling has been linked to human tendon disease. To investigate the effects of chronic HIF1α activation and to compare responses between load-b...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-24 | PXD069118 | Pride
Lc-msms Mouse Tendon Vhl ko 
Proteomicsfunctional biomarker which could be used to predict connective healing based on an Achilles Tendon Model
Healing process after connective tissues (CT) injury is complex but important as CT are critical for human moving, and patient outcome of CT injured patients is protracted with high individual variation. Specific markers which could be used for healing prognosis will be great help to monitor patient...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD033163 | Pride
Ms Connective tissue Healing Fibroblast Eef2 Biomarker 
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