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ProteomicsCardiomyocyte external mechanical unloading activates modifications of alpha-actinin differently from sarcomere-originated unloading
Loss of myocardial mass in a neonatal rat cardiomyocyte culture is studied to determine whether there is a distinguishable cellular response based on the origin of mechano-signals. The approach herein compares the sarcomeric assembly and disassembly processes in heart cells by imposing mechano-signa...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2023-01-05 | MSV000091010 | MassIVE
ProteomicsLoss of α-actinin-3 during human evolution provides superior cold resilience and muscle heat generation
The fast skeletal muscle protein α-actinin-3 is absent in 1.5 billion people worldwide due to homozygosity for a nonsense polymorphism in the ACTN3 gene (R577X). The prevalence of the 577X allele increased as modern humans moved to colder climates, suggesting a link between α-actinin-3 deficiency an...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-16 | PXD022997 | Pride
Α-actinin Evolution Muscle 
ProteomicsIdentifying dynamic protein and RNA proximity interaction networks of actinin reveals RNA-binding and metabolic regulatory mechanisms
We deployed proximity-dependent biotinylation to identify actinin proximity proteins and RNA transcripts in human cardiomyocytes to reveal new functions of the actin cytoskeleton. We identified 285 proximity protein partners including unexpected effectors of RNA-binding and metabolism, and interroga...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD018040 | Pride
Cardiomyocytes Actinin Quantitative proteomics 
GenomicsRNA-Immunoprecipitation Sequencing of Actinin-BirA* vs. Control iPSC-CMs
RNA-Immunoprecipitation Sequencing of Actinin-BirA* vs. Control iPSC-CMs
PRJNA604988 | ENA
ProteomicsReversible SAHH inhibitor protects against glomerulonephritis in lupus-prone NZB/NZW F1 mice by modulating α-actinin-4 associated skeleton organization of podocytes
Glomerulonephritis is one of the major complications and causes of death in systemic lupus erythematosus (SLE). Podocytes can be injured in many forms of glomerular disease, characteristic changes are actin cytoskeleton reorganization of involved foot process. ACTN4, encodes α-actinin-4, an actin-bi...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD010059 | Pride
Α-actinin-4 Integrin-linked kinase Podocyte injury Glomerulonephritis Sahh inhibitor Skeleton organization 
TranscriptomicsGene expression profiles of wild type and Actinin 4 point mutant knock-in adult podocyte cells at 2, 5 and 44 weeks following TRAP purification. (GUDMAP Series ID: 49)
The long term goal is to create an encyclopaedia of podocyte gene expression both in homeostasis, development and disease. Podocytes are identified by their expression of an eGFPL10a fusion protein whose expression is driven by a Col1a1 promoter fragment. Podocyte-specific RNA is generated by eGFP...
ORGANISM(S): Mus musculus 
2014-02-01 | E-GEOD-53156 | biostudies-arrayexpress
ProteomicsSuppressor of IKKepsilon forms direct interactions with cytoskeletal proteins, tubulin and alpha-actinin, linking innate immunity to the cytoskeleton
Suppressor of IKKepsilon (SIKE) is associated with the innate immune system’s type I interferon response through TANK binding kinase 1 (TBK1). Characterized as an endogenous inhibitor of TBK1 when overexpressed in viral infection and pathological cardiac hypertrophic models, mechanistic study revea...
ORGANISM(S): Homo sapiens (Human) 
2018-05-29 | PXD007262 | Pride
Innate immunity Cytoskeleton Sike Tubulin Alpha-actinin 
OtherRNA-Immunoprecipitation Sequencing of Actinin-BirA* vs. Control iPSC-CMs
We found an enrichment of metabolic transcripts in proximity to actinin-BirA*, with sarcomere transcripts being depleted.
ORGANISM(S): Homo sapiens 
2021-08-10 | GSE144806 | GEO
UnknownThe parafibromin tumor suppressor protein interacts with actin-binding proteins actinin-2 and actinin-3.
Not available
S-EPMC2519076 | biostudies-literature
UnknownCharacterisation of Schizosaccharomyces pombe α-actinin.
Not available
S-EPMC4824898 | biostudies-literature
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