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ProteomicsS-acylated and S-palmitoylated proteins in HeLa
S-fatty-acylation is the covalent attachment of long chain fatty acids, predominately palmitate (C16:0, S-palmitoylation), to cysteine (Cys) residues via a thioester linkage on proteins. This post-translational and reversible lipid modification regulates protein function and localization in eukaryot...
ORGANISM(S): Homo sapiens (Human) 
2018-03-28 | PXD008398 | Pride
Hela Label free quatification S-acylation Acyl-rac S-palmitoylation Alk-16 chemical reporter Fatty acylation Lc-ms/ms 
ProteomicsFatty-acylation in RAW264.7 - Bioorthogonal Chemical Reporters for Monitoring Unsaturated Fatty-Acylated Proteins
Dietary unsaturated fatty acids beneficially affect human health, in part by modulating the immune system, but the mechanism is not completely understood. Given that unsaturated fatty acids have been shown to be covalently incorporated into a small subset of proteins, we designed three alkyne-tagged...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-26 | PXD003545 | Pride
Lc-msms Raw264.7 Unsaturated fatty acid Fatty-acylation 
ProteomicsS-acylation and fatty acylation in Naïve and LPS/IFN- gamma activated Raw264.7
The advances in chemical proteomics have significantly expanded our understanding of the diversity and abundance of fatty-acylated proteins in eukaryotes, and reveal novel functions for these lipid protein modifications. Nonetheless, quantitative comparative proteomic analysis of fatty-acylated prot...
ORGANISM(S): Mus musculus (Mouse) 
2018-03-28 | PXD003652 | Pride
Raw264.7 Post translational modifications S-acylation Fatty acylation S-palmitoylation 
ProteomicsChemical proteomics of RID substrates
To globally profile the fatty-acylation substrate proteins of RID, we utilized the bioorthogonal chemical reporter Alk-16, an alkynyl-functionalized fatty acid analogue, to metabolically label fatty-acylated proteins in living cells. To identify the substrate proteins of RID, we sought to perform qu...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD046500 | Pride
Rid Chemical proteomics 
UnknownBifunctional fatty acid chemical reporter for analyzing S-palmitoylated membrane protein-protein interactions in mammalian cells.
Not available
S-EPMC4303541 | biostudies-literature
ProteomicsDirect identification of protein S-palmitoylation sites
S-fatty-acylation is the covalent attachment of long chain fatty acids, predominately palmitate (C16:0, S-palmitoylation), to cysteine (Cys) residues via a thioester linkage on proteins. This post-translational and reversible lipid modification regulates protein function and localization in eukaryot...
ORGANISM(S): Homo sapiens (Human) 
2018-03-28 | PXD008399 | Pride
S-palmitoylation Site identification S-fatty-acylation 
ProteomicsPeptidoglycan metabolite photoaffinity reporters reveal direct binding to intracellular pattern recognition receptors and Arf GTPases
Extensive structure-activity studies of iE-DAP and MDP have demonstrated their selective activation of NOD1- and NOD2-expressing cells, respectively. Nonetheless, the direct binding of iE-DAP and MDP to NOD1 and NOD2, respectively, as well as other proteins in mammalian cells has not been systematic...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD012350 | Pride
Mdp Gel-based proteomics Nod2 Hek293t 
TranscriptomicsGene expression in aerial hyphae in response to rep1 deletion in Ustilago maydis
The rep1 gene of the maize pathogen Ustilago maydis encodes a pre-pro-protein that is processed in the secretory pathway into 11 peptides. These so-called repellents form amphipathic amyloid fibrils at the surface of aerial hyphae. Strains in which the rep1 gene is inactivated (M-bM-^HM-^Frep1 strai...
ORGANISM(S): Ustilago maydis 
2011-05-01 | E-GEOD-21490 | biostudies-arrayexpress
TranscriptomicsGenome-wide screen reveals rhythmic regulation of genes involved in odor processing in the olfactory epithelium
Odor discrimination behavior displays circadian fluctuations in mice indicating that mammalian olfactory function is under control of the circadian system. This is further supported by the facts that odor discrimination rhythms depend on the presence of clock genes and that olfactory tissues contain...
ORGANISM(S): Mus musculus 
2015-11-04 | E-GEOD-69853 | biostudies-arrayexpress
TranscriptomicsTranscriptomic assessment of resistance to effects of an aryl hydrocarbon receptor (AHR) agonist in embryos of Atlantic killifish (Fundulus heteroclitus) from a marine Superfund site
This study presents statistical analyses of gene expression in 5, 10 and 15 day post-fertilization (dpf) embryos of the teleost Fundulus heteroclitus treated with control vehicle (DMSO) or a potent non-ortho-PCB (PCB-126; 3,3’,4,4’,5-pentachlorobiphenyl). The embryos were from two populations: a cl...
ORGANISM(S): Fundulus heteroclitus 
2011-06-06 | E-GEOD-25245 | biostudies-arrayexpress
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