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MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
ProteomicsSystematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulation
Ewing sarcoma (EwS) is characterized by EWSR1-ETS fusion transcription factors converting polymorphic GGAA microsatellites (mSats) into potent neo-enhancers. Although the paucity of additional mutations makes EwS a genuine model to study principles of cooperation between dominant fusion oncogenes an...
ORGANISM(S): Homo sapiens (Human) 
2024-06-18 | PXD052856 | Pride
Cell culture Ewing sarcoma 
ProteomicsHuman, ovarian epithelial cancer cell line, LC-MSMS
We investigated the functions of ECM1 subtypes ECM1a (inlcuding wild type and mutant) and ECM1b in ovarian cancer cell line HEYA8. While ECM1a is oncogenic, ECM1b is a tumor suppressor. To identify the molecules binding to ECM1a or ECM1b within cells, protein samples were generated by co-IP using HA...
ORGANISM(S): Homo sapiens (Human) 
2021-05-27 | PXD025239 | Pride
Human Ecm1 subtypes Ecm1a wild type (wt) Ecm1b Ecm1a mutant (mt) Ovarian epithelial cell line 
ProteomicsHuma Multiple Myeloma Cell line, AMO1, treated with NCP26, LC-MSMS analysis
The human multiple myeloma cell line, AMO1, was treated with NCP26, an ATP-competitive EPRS inhibitor, and a total proteome-wide analysis was performed to determine the effect of NCP26 treatment on protein dynamics.
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD029453 | Pride
Lc-msms Huma Ncp26 Multiple myeloma Cell line Tmt-labeling Amo1 
ProteomicsThermal proteome profiling of childhood ALL cell lines for proteoform detection
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, and it has a 5-year survival rate of 85% for European children. But for subsets of patients who fail to respond to standard of care chemotherapeutics, treatment options are limited, and clinical prognosis is poor. To establish a...
ORGANISM(S): Homo sapiens (Human) 
2023-03-20 | PXD031162 | Pride
Proteoforms Tpp Cetsa Lc-msms All 
Proteomicshuman, gastric cancer line, LC-MSMS
We also tested the downstream differentiation of protein expression between BGC823 Ctrl and BGC823 MIR137HG by IP target FUS following LC-MS/MS. And we selected several proteins related to tumor growth and metastasis to analyze further. String data showed that they might have more contact with each ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD031258 | Pride
Lc-msms Gastric cancer line Human 
ProteomicsCanagliflozin synergises with serine synthesis pathway inhibition mediating anti-leukaemic effects in T-cell acute lymphoblastic leukaemia
T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy commonly driven by NOTCH1 activating mutations. A concomitant feature associated with NOTCH1 mutations is heightened oxidative metabolism enabling the exponential proliferation of T-ALL blasts. As such, targeting mitochondri...
ORGANISM(S): Homo sapiens (Human) 
2025-10-27 | PXD069587 | Pride
Lc-msms T-all Cell line 
ProteomicsA systematic evaluation of semispecific peptide search parameter enables identification of previously undescribed N-terminal peptides and conserved proteolytic processing in cancer cell lines
Background: Liquid chromatography- tandem mass spectrometry (LC-MS/MS) has become the most commonly used technique in explorative proteomic research. A variety of open-source tools for peptide-spectrum matching have become available. Most analyses of explorative MS data are performed using conventio...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2021-03-11 | MSV000087034 | MassIVE
ProteomicsHuman MAP4K proteins TAP-LC-MSMS
Using a systematic proteomic approach, we define the protein-protein interaction network for MAP4K family kinases in human cells and reveal diverse cellular signaling events involving this key kinase family. We conducted a proteomic analysis of 7 MAP4K proteins, each with two biological replicates ,...
ORGANISM(S): Homo sapiens (Human) 
2020-06-29 | PXD016931 | Pride
Human Map4k Tap-lc-msms 
ProteomicsChr16-HPP. Shotgun Analysis improvement. JPR HPP Special issue 2013. CCD18 Cell line.
The Chromosome 16 Consortium is integrated in the Human Proteome Project that aims to develop an entire map of the proteins encoded by the human genome following a gene-centric strategy (C-HPP) to make progress in the understanding of human biology in health and disease (B/D-HPP). To do this study f...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-12 | MSV000083961 | MassIVE
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