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ProteomicsQualitative proteomics analysis of the chicken amniotic fluid
We designed a bottom-up proteomic approach combining two complementary strategies as GeLC-MS/MS (protein samples fractionated by SDS-PAGE are analyzed by nanoLC-MS/MS after in-gel digestion) and shotgun (protein samples are directly analyzed by nanoLC-MS/MS after in-solution digestion) to give an ex...
ORGANISM(S): Gallus gallus (Chicken) 
2018-02-21 | PXD008046 | Pride
Chicken Amniotic fluid Proteomics 
ProteomicsThe Amniotic Fluid Proteome Changes Across Gestation in Humans and Rhesus Macaques
Amniotic fluid is a complex biological medium that offers mechanical protection and nutrition to the fetus, and also plays a key role in normal fetal growth, organogenesis, and potentially fetal programming. Amniotic fluid is also critically involved in longitudinally shaping the in utero milieu dur...
ORGANISM(S): Homo sapiens (Human) Macaca mulatta (Rhesus macaque) 
2023-10-24 | PXD043519 | Pride
Rhesus macaque Isobaric labeling Pregnancy Amniotic fluid Quantitative proteomics 
ProteomicsProteomic Characterization of Cardioprotective Human Acellular Amniotic Fluid
Amniotic fluid-derived products are a promising resource for cell therapy and tissue engineering due to their anti-inflammatory, angiogenic, and antifibrotic properties. Human amniotic fluid (hAF) has been used in medical applications such as wound healing, skin disorders, and ophthalmic conditions....
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053775 | Pride
Human Amniotic fluid Proteomics Lc-ms/ms 
ProteomicsIdentification of new amniotic fluid prognostic biomarkers of congenital cytomegalovirus infection severity
Background: Congenital cytomegalovirus (cCMV) is a common intrauterine infection, leading to neurodevelopmental disabilities. Early prognostic assessment of the severity of cCMV has remained an ongoing challenge. We aimed to identify amniotic fluid biomarkers of the severity of cCMV-related fetal br...
ORGANISM(S): Homo sapiens (Human) Cytomegalovirus sp. 
2022-05-25 | PXD029105 | Pride
Cytomegalovirus  congenital cytomegalovirus infection  amniotic fluid biomarkers 
ProteomicsGestational age-dependent proteome changes in amniotic fluid extracellular vesicles
This study isolated and analysed extracellular vesicles from human amniotic fluid derived from routine second-trimester amniocentesis and elective Caesarean section at term. Label-free proteomics identified 4137 proteins with high confidence.
ORGANISM(S): Homo sapiens (Human) 
2025-06-23 | PXD058882 | Pride
Human Extracellular vesicles Amniotic fluid 
ProteomicsAmniotic fluid proteomics in Congenital Zika Syndrome
In this study, we analyzed by a shotgun proteomic approach the amniotic fluid of pregnant women infected with Zika carrying microcephalic (ZIKV+M+) or healthy fetuses (ZIKV+M-) compared to Zika negative controls (ZIKV-M-) to identify and understand the biological process and pathways affected by CZS...
ORGANISM(S): Homo sapiens (Human) 
2024-07-02 | PXD023776 | Pride
Zika virus  proteomics  microcephaly  amniotic fluid  neutrophil degranulation  extracellular matrix 
ProteomicsIdentification of potential protein biomarkers associated with congenital diaphragmatic hernia in human amniotic fluid
Congenital diaphragmatic hernia (CDH) results from incomplete diaphragm development and can be associated with pulmonary hypoplasia, pulmonary hypertension, and heart failure. Currently, few biomarkers are available. Since amniotic fluid comprises proteins of both fetal and maternal origin, its anal...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD041165 | Pride
Surfactant protein b Osteopontin Galectin-3 Amniotic fluid Kallikrein-5 Proteomics 
ProteomicsComprehensive proteomic investigation of infectious and inflammatory changes in late preterm prelabour rupture of membranes
Preterm prelabour rupture of membranes beyond the 34th week of gestation (late PPROM) is frequently associated with the risk of the microbial invasion of the amniotic fluid (MIAC) and histological chorioamnionitis (HCA). Hence, we employed a Tandem Mass Tag-based approach to uncover amniotic fluid p...
ORGANISM(S): Homo sapiens (Human) 
2020-10-22 | PXD020329 | Pride
Amniotic fluid proteome Tandem mass tag-based lc-ms/ms Late pprom Miac Hca 
ProteomicsQuantification of intra-amniotic inflammation in late preterm prelabour rupture of membranes
Preterm prelabour rupture of membranes (PPROM) complicated by intra-amniotic inflammation (IAI) represents a substantial portion of preterm birth cases. Currently, IAI is frequently defined as amniotic fluid IL-6 concentration above 2600 pg/mL However, the amniotic fluid IL-6 concentration was never...
ORGANISM(S): Homo sapiens (Human) 
2025-04-30 | PXD057800 | Pride
Intra-amniotic inflammation Late pprom Amniotic fluid proteome Il-6 Iai Lc-ms/ms 
ProteomicsProteome analysis of amniotic fluid from fetuses with myelomeningocele from singleton pregnancies
Despite numerous studies on fetal therapy for myelomeningoceles (MMC), the pathophysiology of this malformation remains poorly understood. This study aimed to analyze the biochemical profile and proteome of amniotic fluid (AF) supernatants from MMC fetuses to explore the prenatal pathophysiology. Pr...
ORGANISM(S): Homo sapiens (Human) 
2025-03-13 | PXD048510 | Pride
Myelomeningocele Spina bifida Amniotic fluid 
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