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ProteomicsSurface proteomics reveals CD72 as a target for in vitro-evolved nanobody-based CAR-T cells in refractory B-cell malignancies
Alternate strategies are needed for B-cell malignancy patients relapsing after CD19-targeted immunotherapy. Here, integrated cell surface proteomics and epigenetic analysis initially revealed CD72 as an optimal target for poor-prognosis MLL-rearranged B-ALL, which we further found to be expressed wi...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD016800 | Pride
B-all Cell surface Cd72 
ProteomicsDifferential protein expression of midgut proteins of An. culicifacies species A and species B using iTRAQ approach
Background: Mosquito midgut is an important target for the host parasite interaction studies as this major immune organ plays a role in parasite growth, maturation and vector competence. Most important rural malaria vector of India is Proteomic approaches coupled with bioinformatics analysis have be...
ORGANISM(S): Anopheles culicifacies B Anopheles culicifacies A 
2018-10-24 | PXD003779 | Pride
Itraq method Anopheles Lc/ms/ms Midgut 
ProteomicsAnopheles culicifacies species A and species B Midgut Proteome
Background: Mosquito midgut is an important target for the host parasite interaction studies as it plays a major role in parasite growth and maturation and vector susceptibility. Proteomic approaches coupled with bioinformatics analysis have been used to study expression of functional proteins/enzym...
ORGANISM(S): Anopheles culicifacies B Anopheles culicifacies A 
2018-10-24 | PXD002828 | Pride
Anopheles Lc/ms/ms Refractory Midgut 
ProteomicsIFITM3-mediated regulation of cell membrane dynamics is essential for malignant B-cell transformation
B cell receptor (BCR) signaling and oncogenic tyrosine kinases that mimic BCR-signaling in B-lineage leukemia and lymphoma depend on assembly of membrane proximal signaling complexes. Signalosomes in normal BCR- and oncogene (e.g. BCR-ABL1, RAS-pathway lesions) signal transduction are recruited to p...
ORGANISM(S): Mus musculus (Mouse) 
2020-12-18 | PXD014691 | Pride
Leukemia Bcr signaling Cell surface Lipid rafts 
UnknownVariables affecting the quantitation of CD22 in neoplastic B cells.
Not available
S-EPMC7316386 | biostudies-literature
ProteomicsProteomic analysis of L-Methionine Sulfoximine (MSO)-treated Plasmodium falciparum by LC-MS/MS
LC-MS/MS of in-solution trypsin digested parasite protein extracts was carried out to examine the proteome of MSO-treated Pf parasites. Proteins were extracted from the untreated and MSO-treated parasite pellets of two independent experiments (Exp1: T7_R Vs T8; Exp2: T3_R Vs T4_R). For each experime...
ORGANISM(S): Plasmodium falciparum 58.1 
2023-05-27 | PXD032797 | Pride
Control Plasmodium falciparum (pf) Methionine sulfoximine (mso) Mso-treated 
ProteomicsFood vacuole proteome of P. berghei heme pathway ferrochelatase knockout parasite by LC-MS/MS
LC-MS/MS of in-solution trypsin digested FV protein extracts was carried out for the FVs isolated from PbWT and PbFCKO parasites. The FV preparations had signature FV proteins such as plasmepsin IV, berghepain, aminopeptidases, subunits of vacuolar-type H+ATPase (V-type H ATPase), together with para...
ORGANISM(S): Plasmodium Plasmodium berghei ANKA 
2022-05-10 | PXD031736 | Pride
Knockout (ko) Food vacuole (fv) Wildtype (wt) Plasmodium berghei (pb) Ferrochelatase (fc) 
ProteomicsA CRISPR-engineered Isogenic Model Reveals Altered Neuronal Phenotypes of the 22q11.2 A-B Syndromic Deletion
The 22q11.2 deletion syndrome (22q11.2DS) is the most common copy number variant (CNV)-associated syndrome, leading to congenital and neuropsychiatric anomalies. Patient-derived, induced pluripotent stem cell (iPS) models have provided important insight into the mechanisms of phenotypic features of ...
ORGANISM(S): Homo sapiens (Human) 
2023-05-11 | PXD032075 | Pride
Isogenic Neurons Proteomics Cnv Ipsc 22q11.2ds Crispr Xenotransplant 
TranscriptomicsA genome-wide perspective of miRNAome in response to high temperature, salinity and drought stresses in Brassica juncea (Czern) L.
Purpose: To identify high temperature, sailinity and drought-responsive miRNAs at genome wide level in B. juncea var varuna. Results: In this study four small RNA libraries viz. B. juncea control (BJC), B. juncea high temperature stressed (BJH), B. juncea salinity stressed (BJS) and B. juncea drough...
ORGANISM(S): Brassica juncea 
2014-08-20 | E-GEOD-53242 | biostudies-arrayexpress
UnknownSystematic application of fluorescence in situ hybridization and immunophenotype profile for the identification of ZNF384 gene rearrangements in B cell acute lymphoblastic leukemia.
Not available
S-EPMC7611455 | biostudies-literature
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