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ProteomicsDifferential proteomic analysis of E2F2-/- T lymphocytes
Protein relative quantification based on 2-DE. T lymphocytes were activated with anti CD3 antibody
ORGANISM(S): Mus musculus (Mouse) 
2010-07-20 | PRD000270 | Pride
ProteomicsThe influence of amniotic membrane proteins delivered directly or through hydrogel platforms on corneal regeneration
Purpose: This study has been aimed to investigate corneal wound healing facilitated by two hydrogels loaded with proteins derived from human amniotic membranes (AMs). Methods: Alkaline burns (8 mm diameter) were induced in the corneas of anesthetized male New Zealand White rabbits (n=44) using circu...
ORGANISM(S): Homo sapiens (Human) 
2025-02-11 | PXD055969 | Pride
Wound healing Amniotic membrane Hydrogel inserts Cornea Rabbit 
ProteomicsThe structural and functional significance of Aedes aegypti AgBR1 flavivirus immunomodulator
Zika virus, an arbovirus, relies on mosquitoes as vectors for its spread and transmission. During blood feeding mosquitoes inoculate saliva containing various proteins. Recently, AgBR1, an Aedes aegypti salivary gland protein, has garnered attention for its immunomodulatory viral activity, along wit...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-04 | PXD052671 | Pride
Mosquito salivary proteins Immunomodulators Zika virus 
ProteomicsPotential tear biomarkers for the early diagnosis of Parkinson's disease- A pilot study
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. The purpose of this study was to analyze the profile of the tear proteome of patients with idiopathic PD (iPD), carriers of the E46K-SNCA mutation and healthy subjects (CT) and to identify biomark...
ORGANISM(S): Homo sapiens (Human) 
2022-02-14 | PXD028811 | Pride
Biomarkers  parkinson’s disease  tear film  lysosome 
ProteomicsN7-methylguanosine methylation of tRNAs regulates survival to stress in cancer
Combining transcriptome-wide approaches to detect m7G RNA methylation, in vitro functional assays and Mettl1 knockout mouse models, we provide evidence that guanosine-7 tRNA methylation is required to protect tRNAs from cleavage in response to stress, leading to impaired regulation of protein synthe...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD036009 | Pride
Autophagy 7-methylguanosine Synthetic lethality. Prostate cancer Survival Trna fragments Epitranscriptome Senescence Cytotoxic stress 
ProteomicsHuman serum extracellular vesicle proteomic profile depends on the enrichment method employed
The proteomic profiling of serum samples supposes a challenge due to the large abundance of few blood proteins in comparison with other circulating proteins coming from different tissues and cells. Although the sensitivity of protein detection has increased enormously in the last years, to enrich le...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD029015 | Pride
Ultracentrifugation Extracellular vesicles Serum Precipitation kits Size exclusion Proteomic 
ProteomicsProteomic evaluation of human osteoblast responses to titanium implants over time
Titanium is widely used in bone prostheses due to its excellent biocompatibility and osseointegration capacity. To understand the effect of sandblasted acid-etched (SAE) Ti implants on the biological responses of human osteoblast (HOb), their proteomic profiles were analysed using nLC-MS/MS. The cel...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035986 | Pride
Titanium Human osteoblasts Label free 
ProteomicsCharacterization of PITH domain-containing protein 1 (C1orf128) functionality in olfactory metabolism
Taking into account the relevance of the smell sense in the early diagnosis of neurodegenerative diseases, we have analyzed the expression profile of the dark proteome across public proteomic and transcriptomic data derived from primary olfactory areas such as olfactory bulb (OB) and cleft mucus as ...
ORGANISM(S): Homo sapiens (Human) 
2020-11-19 | PXD018784 | Pride
Tmt Timstof Hpp Pithd1 
ProteomicsProteomics reveals differential diagnosis biomarkers between sepsis and hemophagocytic syndrome
Hemophagocytic Lymphohistiocytosis (HLH) shares many clinical features with sepsis. To improve HLH diagnosis and its differential diagnosis with sepsis, serum proteomic analyses of healthy donors, HLH and septic patients were performed. In this study, 24 individuals were enrolled in a label free MS/...
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD063444 | Pride
Hemophagocytic syndrome Sepsis Label free 
ProteomicsTear protein profile in eyes with keratoconus after one year of intrastromal corneal ring and corneal crosslinking: a pilot study
Keratoconus (KC) is a corneal ectasia characterized by structural changes, resulting in progressive thinning and biomechanical weakening that can lead to worsening visual acuity due to irregular astigmatism. Corneal collagen Crosslinking (CXL) and Intracorneal Ring Segment (ICRS) are widely used tr...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD035655 | Pride
Keratoconus Intracorneal ring segment Crosslinking Tear film 
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