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UnknownAraC-like transcriptional activator CuxR binds c-di-GMP by a PilZ-like mechanism to regulate extracellular polysaccharide production.
Not available
S-EPMC5474780 | biostudies-literature
ProteomicsStructure of the minimal type I-F2 CRISPR-Cas DNA-interference complex
CRISPR–Cas systems provide adaptive immunity in prokaryotes by targeting and degrading invasive genetic elements. Among them, the type I-F2 system represents the most compact type I CRISPR–Cas system, distinguished by the absence of small and large subunits. These subunits are otherwise essential fo...
ORGANISM(S): Shewanella putrefaciens CN-32 
2026-03-09 | PXD068253 | Pride
Cryo-em Shewanella putrefaciens Hdx-ms Dna interference Interference complex 
ProteomicsRetron Eco2 breaks tRNAs for anti-phage defense
Retrons mediate bacterial anti-phage defense by reverse transcribing non-coding RNA into multicopy single-stranded DNA (msDNA). Our study reveals the unique trimeric nucleoprotein structure of Eco2, which solely relies on a single protein for defense, unlike most other retrons. This structure suppor...
ORGANISM(S): Escherichia coli 
2026-02-03 | PXD060313 | Pride
Retron Cryo-em Hdx-ms Anti-phage defense 
Proteomicsc-di-GMP-induced conformational dynamics of the c-di-GMP-binding protein A (CdbA) from Myxococcus xanthus
The second messenger c-di-GMP has important functions in response to changing environmental and cellular cues in bacteria. Here, we report the identification of CdbA, a DNA binding protein of the ribbon-helix-helix family in Myxococcus xanthus, and show that it binds c-di-GMP in vitro. CdbA is essen...
ORGANISM(S): Myxococcus xanthus DK 1622 
2020-04-16 | PXD018028 | Pride
C-di-gmp Plgs Hdx-ms Dynamx 
ProteomicsInteraction of human eIF5A and DHS K329A variant studied by HDX-MS
Hypusination is a unique post-translational modification of the eukaryotic translation factor 5A (eIF5A) that is essential for overcoming ribosome stalling at polyproline sequence stretches. The initial step of hypusination, the formation of deoxyhypusine, is catalyzed by deoxyhypusine synthase (DHS...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2023-05-10 | PXD040460 | Pride
Eif5a Hdx-ms Synapt-g2 si Dhs k329a variant 
ProteomicsA protein adaptor mediating Ap4A-dependent control of protein acetylation.
Reversible lysine acetylation is a highly conserved post-translational modification across all domains of life, modulating diverse cellular processes. However, the regulatory mechanisms governing this modification remain poorly understood. Here, we uncover a novel regulatory system in Bacillus subti...
ORGANISM(S): Geobacillus thermodenitrificans NG80-2 
2026-01-21 | PXD064203 | Pride
Lysine acetylation Cbs Hdx-ms Ap4a 
ProteomicsPausing protein acetylation by an Ac-CoA synthetase/acetyltransferase complex.
Acetyl-CoA synthetase (Acs) generates acetyl-Coenzyme A (Ac-CoA) but its excessive activity can deplete ATP and lead to growth arrest. To prevent this, Acs is tightly regulated through Ac-CoA-dependent feedback inhibition executed by Ac-CoA-dependent acetyltransferases such as AcuA in Bacillus subti...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2025-02-28 | PXD058390 | Pride
Acsa Cryo-em Protein acetylation Hdx-ms Acua 
ProteomicsMolecular basis of ParA ATPase activation by the CTPase ParB during bacterial chromosome segregation
DNA segregation by bacterial ParABS systems is mediated by transient tethering interactions between nucleoid-bound dimers of the ATPase ParA and centromere (parS)-associated complexes of the clamp-forming CTPase ParB. The lifetime of these interactions is limited by the ParB-dependent activation of ...
ORGANISM(S): Myxococcus xanthus DK 1622 
2025-08-11 | PXD063735 | Pride
Soj Enzyme regulation Dna relay Atp hydrolysis Sopa Bacteria Para/mind family Protein-protein interaction Walker atpase Molecular switch Nucleotide 
ProteomicsStructural dynamics of the chicken TRPV4 N-terminal domain
Intrinsically disordered regions (IDRs) are essential for membrane receptor regulation but often remain unresolved in structural studies. TRPV4, a member of the TRP vanilloid channel family involved in thermo- and osmosensation, has a large N-terminal IDR of approximately 150 amino acids. With an in...
ORGANISM(S): Escherichia coli Gallus gallus (Chicken) 
2023-10-24 | PXD041067 | Pride
Trpv4 
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