Sort   by:  
 Page size 
We used HDXMS to study the confomational changes induced in a PIKfyve construct upon binding PI3P membrane and a variety of inhibitors. Here we showed a significant protection in deuterium exchange upon binding all inhibitors, and regions of protection and exposure upon binding PI3P membrane.
ORGANISM(S): Homo sapiens (Human) 
2025-10-15 | PXD044706 | Pride
The origin of humans was accompanied by the emergence of new behavioral and cognitive functions, including language and specialized forms of abstract representation. However, the molecular foundations of these human capabilities are poorly understood. Because of the extensive similarity between huma...
ORGANISM(S): Pan troglodytes 
This project containins data for K562 cell line experiments with SF3B1 Mutations
ORGANISM(S): Homo sapiens (Human) 
2024-11-20 | PXD030127 | Pride
Hotspot mutations in the spliceosomal component gene SF3B1 underpin a number of cancers and have a neomorphic function leading to global disruption of canonical splicing and aberrant splicing of hundreds of transcripts. However, the functional consequences of this misplicing and resultant genetic vu...
ORGANISM(S): Homo sapiens (Human) 
2023-04-19 | PXD019046 | Pride
Sort   by:  
 Page size