Sort   by:  
 Page size 
ProteomicsProteomics analysis with the WDR5 PROTACs
Active gene transcription requires accessible chromatin. Post-translational modifications of histone proteins modulate accessibility to target genes, a process that is controlled by multiple chromatin modifying enzymes, remodelers and epigenetic reader proteins. Histone H3K4 methylation serves as ha...
ORGANISM(S): Homo sapiens (Human) 
2022-01-27 | PXD025257 | Pride
Lc-msms Protac Protein degrader Wdr5 
ProteomicsNovel, highly potent PROTACs targeting AURORA-A kinase
The family of AURORA kinases is essential for cell cycle progression and dysregulation of AURORA-A in cancer led to a large number of clinical and pre-clinical inhibitors. However, ATP competitive AURORA-A inhibitors usually do not target non-catalytic functions that have also been identified as mec...
ORGANISM(S): Homo sapiens (Human) 
2023-09-14 | PXD033239 | Pride
Lc-msms Aurka Protac Protein degrader 
ProteomicsStructure-based Scaffold Hopping Reveals Strategies to Overcome Oncogenic KIT and PDGFRA Mutation-Driven Drug-Resistance in GIST
Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract. Current tyrosine kinase inhibitors (TKIs) targeting oncogenic KIT and PDGFRA have improved patient outcomes, yet off-target toxicities and drug resistance mutations remain major clinical chal...
ORGANISM(S): Homo sapiens (Human) 
2026-08-03 | PXD077574 | Pride
Selectivity profiling Gist Pdgfra Kit Drug resistance Kinobeads 
ProteomicsAURORA A interacts with DICER and SETD2 and promotes S-phase progression
The oncogenic kinase AURORA A is essential for mitotic progression, and its catalytic inhibition arrests cells at the G2/M-transition. Unexpectedly, degradation of AURORA A by PROTACs (proteolysis targeting chimeras) induces profound S-phase defects, revealing a non-catalytic scaffolding function of...
ORGANISM(S): Homo sapiens (Human) 
2026-07-01 | PXD076528 | Pride
Dicer Aurka R-loops Aurora a Protacs 
Sort   by:  
 Page size