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ProteomicsTTC30A and TTC30B redundancy protects IFT complex B integrity and its pivotal role in ciliogenesis
Intraflagellar transport (IFT) is a microtubule-based system that supports the assembly and maintenance of cilia, an essential organelle for development and maintenance of cellular integrity. Dysfunction of IFT was shown to lead to a wide spectrum of disease phenotypes, so called ciliopathies of var...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD034412 | Pride
Ttc30 Cilia Ift-b 
ProteomicsCiliopathy-associated missense mutations in IFT140 are hypomorphic and have edgetic effects on protein interaction networks
The mechanisms underlying recessive Mendelian diseases and the interplay between genotype and phenotype still need to be better understood. It is therefore necessary to characterise the functional effects of missense mutations at the protein level. Here we focus on missense mutations in the intrafla...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD044186 | Pride
Cilia Intraflagellar transport Protein interaction Ciliopathy Hypomorph Missense mutation Edgetic 
UnknownTolerance induction through non-avoidance to prevent persistent food allergy (TINA) in children and adults with peanut or tree nut allergy: rationale, study design and methods of a randomized controlled trial and observational cohort study.
Not available
S-EPMC8962184 | biostudies-literature
ProteomicsCRISPR/Cas9-mediated knockout and endogenous complex analysis of Cluap1/ IFT38
CRISPR/Cas9-mediated gene-editing allows manipulation of a gene of interest in its own chromosomal context. When applied to the analysis of protein interaction, and in contrast to an exogenous expression of a protein, these can be studied maintaining physiological stochiometries, topology and contex...
ORGANISM(S): Homo sapiens (Human) 
2018-04-04 | PXD008343 | Pride
Cilia Proteomics Crispr/cas9 Ift 
ProteomicsTissue-specific protein complex analysis with natively processed bait proteins
Protein-protein interaction analysis is an important tool to elucidate the function of proteins and protein complexes as well as their dynamic behavior. Despite the large toolset available to date the analysis of tissue specific complexes is still relying on the availability of specific antibodies s...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2023-12-28 | PXD018047 | Pride
Tissue-specific protein complex analysis Isoform-specific 
ProteomicsTissue- and isoform-specific protein complex analysis with natively processed bait proteins
Protein-protein interaction analysis is an important tool to elucidate the function of proteins and protein complexes as well as their dynamic behavior. To date, the analysis of tissue- or even cell- or compartment-specific protein interactions is still relying on the availability of specific antibo...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2023-12-28 | PXD020379 | Pride
Flag tag Tissue-specific complex 
ProteomicsIdentification of novel blood-borne soluble binding partners of factor H-related proteins
The deposition of circulating complement factor H-related (FHR) proteins in tissues around the body has been implicated in a series of complement-mediated diseases. However, the array of blood-borne binding partners with which they interact remains unclear. Here, we identify novel blood-borne bindin...
ORGANISM(S): Homo sapiens (Human) 
2026-03-30 | PXD072296 | Pride
Fhr Affinity proteomics Blood 
ProteomicsParalogue specific TTC30A knockout downregulates Sonic hedgehog signaling
Cilia assembly, maintenance and the localization of signal-transduction proteins necessitate a functioning intraflagellar transport (IFT). The IFT machinery moves cargo along a microtubule scaffold from the proximal to the distal end of the cilium. This anterograde transport is facilitated by a larg...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD044183 | Pride
Ttc30 paralogues Sonic hedgehog signaling Affinity proteomics Ift Pka Cilia 
ProteomicsInteractome analysis reveals a link of the novel ALMS1-CEP70 complex to centrosomal clusters
Alström syndrome (ALMS) is a very rare autosomal-recessive disorder, causing a broad range of clinical defects most notably retinal degeneration, type 2 diabetes and truncal obesity. The ALMS1 gene codes for a ~0.5 MDa protein, which has hampered analysis in the past. Interestingly, ALMS1 has been s...
ORGANISM(S): Homo sapiens (Human) 
2024-01-25 | PXD046401 | Pride
Cilia Centrosome Basal body Ciliopathy Alström syndrome Crispr/cas9 Protein complex analysis 
TranscriptomicsNuclear tRNA sequestering slows aging by a mechanism similar to dietary restriction
Dietary restriction (DR) is the best-characterized intervention for slowing aging, and reduced signaling through the target of rapamycin (TOR) kinase is believed to be one of the key mechanisms by which DR extends life span in organisms from yeast to mammals. Here we describe a role for nuclear seq...
ORGANISM(S): Saccharomyces cerevisiae 
2015-02-03 | E-GEOD-37241 | biostudies-arrayexpress
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