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ProteomicsProteolytic information flows from human knee osteoarthritic cartilage to synovial fluid and defines the roles of key drug targets -1
Objectives: Proteolytic cartilage loss is a major mechanism of osteoarthritis (OA) pathogenesis but few joint breakdown biomarkers are currently available. We sought to determine the overlap of proteolytic peptides in OA cartilage and synovial fluid on a proteome-wide scale with the goals of increa...
ORGANISM(S): Homo sapiens (Human) 
2025-02-04 | PXD048053 | Pride
Proteolysis Synovial fluid Cartilage Protease Proteomics Osteoarthritis 
ProteomicsIdentification of potential protein biomarkers associated with congenital diaphragmatic hernia in human amniotic fluid
Congenital diaphragmatic hernia (CDH) results from incomplete diaphragm development and can be associated with pulmonary hypoplasia, pulmonary hypertension, and heart failure. Currently, few biomarkers are available. Since amniotic fluid comprises proteins of both fetal and maternal origin, its anal...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD041165 | Pride
Surfactant protein b Osteopontin Galectin-3 Amniotic fluid Kallikrein-5 Proteomics 
ProteomicsConsequences of fibroblast ablation in adult murine hearts
Fibroblasts produce the majority of collagen in the heart and are thought to regulate extracellular matrix (ECM) turnover. However, the in vivo role of fibroblasts in structuring the basal ECM network is poorly understood. To examine the effects of fibroblast loss on the microenvironment in the adul...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD021741 | Pride
Shotgun Murine Fibroblast ablated Labelfree analysis 
ProteomicsADAMTS7, a target in atherosclerosis, cooperates with homolog ADAMTS12 to protect against myxomatous valve degeneration
The metalloprotease ADAMTS7, a drug target in atherosclerosis and vascular restenosis, is thought to have no relevant physiological role in the cardiovascular system. However, potential cooperation with its close homolog, ADAMTS12, that may mask such a role remains unexplored. The objective of the p...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-05-07 | PXD055550 | Pride
Metalloproteinase Hypertrophy Chondroitin sulfate Heart valve Fibrosis Adamts Regurgitation Extracellular matrix Myxomatous valve 
ProteomicsCombined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases uncovers a requirement for versican and glypican-6 proteolysis in cardiac development-1
Background: Extracellular matrix remodeling mechanisms are understudied in cardiac development and congenital heart defects. Two similar matrix-degrading metalloproteases, ADAMTS1 and ADAMTS5, are extensively co-expressed during mouse cardiac development. The mouse mutants of each have mild cardiac ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-05-06 | PXD045868 | Pride
Proteomics Cardiac jelly Proteases Tetralogy of fallot Proteoglycan Trabeculation 
ProteomicsForward and reverse degradomics defines the proteolytic landscape of human knee osteoarthritic cartilage and the role of the serine protease HtrA1
Proteolytic destruction of articular cartilage is a major pathogenic mechanism in osteoarthritis (OA), but was not previously investigated on a proteome-wide scale. We sought to define the human knee OA cartilage degradome and the contribution therein of the serine protease HtrA1, using an N-termino...
ORGANISM(S): Homo sapiens (Human) 
2023-11-03 | PXD028320 | Pride
Degradomics Atoms Osteoarthritis N-terminomics Htra1 
ProteomicsIdentification of potential protein biomarkers associated with congenital diaphragmatic hernia in human amniotic fluid
Congenital diaphragmatic hernia (CDH) is a severe birth defect frequently associated with pulmonary hypoplasia, pulmonary hypertension, and heart failure. Since amniotic fluid comprises proteins of both fetal and maternal origin, its analysis could provide insights on mechanisms underlying CDH and p...
ORGANISM(S): Homo sapiens (Human) 
2023-11-03 | PXD041859 | Pride
Surfactant protein b Osteopontin Galectin-3 Amniotic fluid Kallikrein-5 Proteomics 
ProteomicsForward and reverse degradomics defines the proteolytic landscape of human knee osteoarthritic cartilage and the role of the serine protease HtrA1
Proteolytic destruction of articular cartilage is a major pathogenic mechanism in osteoarthritis (OA), but was not previously investigated on a proteome-wide scale. We sought to define the human knee OA cartilage degradome.
ORGANISM(S): Homo sapiens (Human) 
2023-11-03 | PXD028060 | Pride
Cartilage Serine protease Osteoarthritis Htra1 
ProteomicsConsequences of fibroblast ablation in adult murine hearts
Fibroblasts produce the majority of collagen in the heart and are thought to regulate extracellular matrix (ECM) turnover. However, the in vivo role of fibroblasts in structuring the basal ECM network is poorly understood. To examine the effects of fibroblast loss on the microenvironment in the adul...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD021739 | Pride
Fibroblast ablated Tails Hearts Murine N-terminomics 
ProteomicsCombined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases uncovers a requirement for versican and glypican-6 proteolysis in cardiac development.
Background: Extracellular matrix remodeling mechanisms are understudied in cardiac development and congenital heart defects. Two similar matrix-degrading metalloproteases, ADAMTS1 and ADAMTS5, are extensively co-expressed during mouse cardiac development. The mouse mutants of each have mild cardiac ...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD045706 | Pride
Proteomics Cardiac jelly Proteases Tetralogy of fallot Proteoglycan Trabeculation 
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