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MetabolomicsMulti-hierarchical profiling the structure-activity relationships of engineered nanomaterials at nano-bio interfaces
Increasing concerns over the possible risks of nanotechnology necessitates breakthroughs in structure-activity relationship (SAR) analyses of engineered nanomaterials (ENMs) at nano-bio interfaces. However, current nano-SARs are often based on univariate assessments and fail to provide tiered views ...
2020-01-23 | MTBLS721 | MetaboLights
MetabolomicsHigh microbiome and metabolome diversification in coexisting sponges with different bio-ecological traits

Marine sponges can host abundant and diverse microbiomes, which can largely influence the metabolism and other phenotypic traits of the host. However, information on the potential relationships between sponge microbiomes and metabolic signatures, other than secondary metabolites explored for biot...

2024-02-21 | MTBLS5125 | MetaboLights
MetabolomicsExploiting Vitamin B6 Dependency: BVL3572S Inhibits HisC and AlaA to Kill Mycobacterium tuberculosis

Tuberculosis remains the leading cause of death from a single infectious agent worldwide, and the growing prevalence of multi-drug resistant Mycobacterium tuberculosis (Mtb) underscores the urgent need for antibiotics with novel mechanisms of action. Here, we characterize BVL3572S, a hydroxamic a...

2026-06-23 | MTBLS14782 | MetaboLights
TranscriptomicsExpression analysis of shoots in Olea europaea cultivar M-bM-^@M-^XArbequinaM-bM-^@M-^Y collected at different growth time
Genetic changes involved in the juvenile-to-adult transition in the shoot apex of Olea europaea L. occurs years before the first flowering. For the study of the genetic-expression pattern over development, 21 seedlings originating from open pollination of olive cultivar M-bM-^@M-^XArbequinaM-bM-^@M-...
ORGANISM(S): Olea europaea 
2013-11-09 | E-GEOD-52213 | biostudies-arrayexpress
TranscriptomicsTranscript analyses of cisplatin and Sky1 effects in Saccharomyces cerevisiae
Sky1 is a Saccharomyces cerevisiae rich serine-arginine (SR) protein-specific kinase and its enzymatic activity is essential in the cytotoxicity caused by cisplatin, although the molecular mechanisms supporting this function are not understood. We present a transcriptome analysis discriminating betw...
ORGANISM(S): Saccharomyces cerevisiae 
2014-08-01 | E-GEOD-41094 | biostudies-arrayexpress
TranscriptomicsGene expression of bone marrow fibroblasts from monoclonal gammopathy of undetermined significance and active multiple myeloma.
Fibroblasts are a key cellular component of tumour microenvironment, along with other stromal cells playing a critical role in disease initiation and progression (1). In this study, bone marrow fibroblasts deriving from patients with monoclonal gammopathy of undetermined significance (MGUS) or activ...
ORGANISM(S): Homo sapiens 
2010-10-30 | E-GEOD-24990 | biostudies-arrayexpress
TranscriptomicsInfluence of 17M-NM-2-estradiol on Gene Expression of Paracoccidioides During Mycelia-to-Yeast Transition
Background: Paracoccidioides is the causative agent of paracoccidioidomycosis, a systemic mycosis endemic to Latin America. Infection is initiated by inhalation of conidia (C) or mycelial (M) fragments, which subsequently differentiate into yeast (Y). Epidemiological studies show a striking predomin...
ORGANISM(S): Paracoccidioides brasiliensis Pb01 
2011-12-14 | E-GEOD-30466 | biostudies-arrayexpress
ProteomicsBacillus thuringiensis Cry5, Cry21, App6 and Xpp55 proteins to control the plant pest nematodes Meloidogyne javanica and M. incognita
The global imperative to enhance crop protection while preserving the environment has increased interest in the application of biological pesticides. Bacillus thuringiensis (Bt) is a Gramm-positive bacterium that can produce nematicidal proteins and accumulate them in parasporal crystals. Root-knot ...
ORGANISM(S): Bacillus thuringiensis 
2025-05-07 | PXD053413 | Pride
Bio-control Bioassay In vitro assay Bt wild strains In planta assay 
ProteomicsProteome analysis of the M. tuberculosis Beijing B0/W148 cluster
The main project purpose is to investigate the fundamental physiological state of M. tuberculosis (MTB) during the infection and the mycobacterial response within the infected host tissue, human lung. High-throughput proteomic analysis of MTB cells will be involved to solve this problem. The descrip...
ORGANISM(S): Mycobacterium tuberculosis Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis SP1 Mycobacterium tuberculosis SP22 Mycobacterium tuberculosis SP10 Mycobacterium tuberculosis SP13 Mycobacterium tuberculosis SP7 
2016-07-06 | PXD002542 | Pride
Tuberculosis Mtb Beijing Lc-ms/ms 
ProteomicsPhosphoproteomic characterization of infulenza A virus infected human macrophages
Human primary macrophages were infected with influenza A virus (H3N2/Udorn strain, HA 256) for 6 hrs or left untreated. Cells were collected and lysed with HEPES lysis buffer (50 mM HEPES, 150 mM NaCl, 1 mM EDTA, 1 % NP-40, pH 7.4) including protease and phosphatase inhibitor cocktails. The cell lys...
ORGANISM(S): Homo sapiens (Human) 
2016-08-08 | PXD001620 | Pride
Primary human macrophages Phosphorylation Influenza a virus 
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