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ProteomicsLC-MSMS of Hela cell extracts on pull down with de novo modular peptide binding proteins
we describe a general approach for de novo design of proteins made out of repeating units that bind peptides with repeating sequences such that there is a one to one correspondence between repeat units on the protein and peptide. We develop a rapid docking plus geometric hashing method to identify p...
ORGANISM(S): Homo sapiens (Human) 
2023-03-17 | PXD038492 | Pride
Hela Gelbands Lc-msms 
Proteomics2 integrins impose a mechanical checkpoint on macrophage phagocytosis
Phagocytosis is an intensely physical process that depends on the mechanical properties of both the phagocytic cell and its chosen target. Here, we employed differentially deformable hydrogel microparticles to examine the role of cargo rigidity in the regulation of phagocytosis by macrophages. Where...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-22 | PXD049434 | Pride
Mouse Lc-ms 
ProteomicsInterrogating the interaction of fission yeast RNA-binding protein Puf3 with the Ccr4-Not complex using crosslinking mass spectrometry
mRNA decay is a key determinant of gene regulation, initiated by the shortening of mRNA poly(A) tails by the CCR4-NOT deadenylation complex. Specificity is achieved through RNA adaptors—RNA-binding proteins that recruit CCR4-NOT to specific substrate mRNAs in a regulated manner. However, the molecul...
ORGANISM(S): Schizosaccharomyces pombe 927 
2025-09-03 | PXD055147 | Pride
Crosslinking ms Idr Protein-protein interaction Rna binding protein puf3 Ccr4-not complex 
ProteomicsPITX2 defiency identifies changes in sarcomere structure and mitochondrial dysfunktion as substrates for atrial fibrillation
Atrial fibrillation affects 2-3% of the population and is associated with high morbidity and mortality from cardiovascular causes in patients. Common gene variants on chromosome 4q25 show the strongest genomic disease association and reside in an enhancer region regulating the Paired like Homeodomai...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD037189 | Pride
Cardiomyocytes Stem cell Pitx" knockout 
UnknownEffects of intensive blood-pressure control in type 2 diabetes mellitus.
Not available
S-EPMC4123215 | biostudies-literature
UnknownEffects of medical therapies on retinopathy progression in type 2 diabetes.
Not available
S-EPMC4026164 | biostudies-literature
UnknownMortality results from a randomized prostate-cancer screening trial.
Not available
S-EPMC2944770 | biostudies-literature
UnknownColorectal-cancer incidence and mortality with screening flexible sigmoidoscopy.
Not available
S-EPMC3641846 | biostudies-literature
UnknownIncorporating Concomitant Medications into Genome-Wide Analyses for the Study of Complex Disease and Drug Response.
Not available
S-EPMC5013254 | biostudies-literature
UnknownEffects of combination lipid therapy in type 2 diabetes mellitus.
Not available
S-EPMC2879499 | biostudies-literature
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