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ProteomicsEffects of prenylcysteine oxidase 1 (PCYOX1) silencing on HepG2 cell secretome
We performed a label free mass spectrometry-based proteomic analysis to investigate the effects of PCYOX1 silencing on the secretome of human HepG2 cells
ORGANISM(S): Homo sapiens (Human) 
2021-10-12 | PXD022302 | Pride
Pcyox1 Secretome Hepg2 
UnknownData for proteomic analysis of Human monocyte-derived macrophages.
Not available
S-EPMC4510452 | biostudies-literature
ProteomicsGender differences in human endothelial cell secretome
We performed proteomic and gene ontology (GO) analyses of secretome from human serum-deprived male and female endothelial cells (ECs).
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020375 | Pride
Endothelial cells Human Secretome Gender 
ProteomicsThe effects of silencing PTX3 oin the proteome of human endothelial cells
The human long pentraxin PTX3 has complex regulatory roles at the crossroad of innate immunity, inflammation, and tissue repair. PTX3 can be produced by various cell types, including vascular endothelial cells (ECs), in response to pro-inflammatory cytokines or bacterial molecules. But PTX3 has also...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD036691 | Pride
Endothelial cells Label-free mass spectrometry Ptx3 
ProteomicsNormal human mitral valve proteome: a preliminary investigation by gel-based and gel-free proteomic approaches
The mitral valve is a highly complex structure which regulates blood flow from the left atrium to the left ventricle (LV) avoiding a significant forward gradient during diastole or regurgitation during systole. The integrity of the mitral valve is also essential for the maintenance of normal LV size...
ORGANISM(S): Homo sapiens (Human) 
2016-08-18 | PXD004397 | Pride
Human normal mitral valve Lc/mse Valvular interstitial cells 
UnknownA molecular and computational diagnostic approach identifies FOXP3, ICOS, CD52 and CASP1 as the most informative biomarkers in acute graft-versus-host disease.
Not available
S-EPMC3507302 | biostudies-literature
ProteomicsThe effects of silencing PCYOX1 on the proteome of murine fibroblast cells 3t3-L1 differentiated to adipocyte-like cells
In order to evaluate the impact of PCYOX1 deletion on adipogenesis, we applied a label-free mass spectrometry-based proteomic approach to compare the proteome of 3T3-L1 differentiated for 9 days to adipocytes after PCYOX1 gene silencing. Pcyox1 was silenced using shRNA lentiviral particles. Control ...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD039943 | Pride
3t3-l1 cells Label-free mass spectrometry Pcyox1 
TranscriptomicsExpression data for 2 obese subjects from the SibPair cohort with a deletion on 16p11.2
We report a highly-penetrant form of obesity, initially observed in 31 heterozygous carriers of a 593kb or larger deletion at 16p11.2 from amongst subjects ascertained for cognitive deficits. Nineteen similar deletions were identified from GWAS data in 16053 individuals from 8 European cohorts; such...
ORGANISM(S): Homo sapiens 
2009-12-02 | E-GEOD-19238 | biostudies-arrayexpress
ProteomicsZc3h10 is a novel mitochondrial regulator
Mitochondria are the energy-generating hubs of the cell. In spite of considerable advances, our understanding of the factors that regulate the molecular circuits that govern mitochondrial function remains incomplete. Using a genome-wide functional screen, we have identified the poorly characterized ...
ORGANISM(S): Mus musculus (Mouse) 
2018-03-06 | PXD008833 | Pride
Zc3h10 Mitochondria Energy metabolism Oxidative phosphorylation. 
UnknownPrenylcysteine Oxidase 1 Is a Key Regulator of Adipogenesis.
Not available
S-EPMC10045348 | biostudies-literature
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