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ProteomicsBrown bear skeletal muscle quantitative LC-MSMS
Muscle atrophy is one of the main deleterious consequences of ageing and physical inactivity. Although basic knowledge regarding the underlying mechanisms of muscle atrophy is continuously growing, there are still no efficient therapeutic strategies for its prevention and treatment. Hibernating bear...
ORGANISM(S): Ursus arctos (Brown bear) (Grizzly bear) 
2019-05-14 | PXD004908 | Pride
Lc-msms Skeletal muscle Hibernation Bears 
ProteomicsMultiple reaction monitoring assays for large-scale quantitation of proteins from 20 mouse organs and tissues
We developed 7,184 quantitative multiple reaction monitoring mass spectrometry (MRM-MS) assays that measure 2,118 unique proteins in 20 mouse organs and tissues to enable system-level analysis of protein expression in mice. Targets for assay development were selected by untargeted MS analysis, and c...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-03 | PXD021333 | Pride
Mouse tissue proteomics Proteomic phenotyping Mrm assay development Cptac Molecular phenotyping Stable isotope-labelled standards 
ProteomicsBrown bear skeletal muscle 2D-DIGE-LC-MSMS
Muscle atrophy is one of the main deleterious consequences of ageing and physical inactivity. Although basic knowledge regarding the underlying mechanisms of muscle atrophy is continuously growing, there are still no efficient therapeutic strategies for its prevention and treatment. Hibernating bear...
ORGANISM(S): Ursus arctos arctos (European brown bear) 
2019-05-14 | PXD011687 | Pride
Lc-msms Skeletal muscle Hibernation Bears 2d-dige 
ProteomicsTissue proteome of visceral, subcutaneous and brown adipose as well as liver tissues in an obese mouse model after dietary exposure to the emerging phthalate substitute DINCH
Here, we analysed the global proteome of visceral, subcutaneous and brown adipose as well as liver tissues in a C57BL/6J mouse model of diet-induced obesity, following dietary exposure to 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH). This study includes data on male and female mice, as...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-03 | PXD054970 | Pride
Tissue proteomics Obesity Dinch Mouse 
ProteomicsQuantitative proteomics of brown bear muscle during hibernation
During hibernation, the physiology of bears is characterized by strong metabolic depression. In skeletal muscles, lipids are used as the main energy fuels although their oxidation rate is reduced, and glycolysis appears maintained likely feeding the Cori cycle. For a better knowledge on proteome rem...
ORGANISM(S): Ursus arctos (Brown bear) (Grizzly bear) 
2026-03-02 | PXD060503 | Pride
Lc-msms Metabolic depression Bear Hibernation Muscle 
UnknownCysteine S-acetylation is a widespread post-translational modification on metabolic proteins.
Not available
S-EPMC12594830 | biostudies-literature
UnknownRegulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation.
Not available
S-EPMC6525068 | biostudies-literature
UnknownBCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis.
Not available
S-EPMC11145561 | biostudies-literature
UnknownA real-world retrospective study of the use of Ki-67 testing and treatment patterns in patients with HR+, HER2- early breast cancer in the United States.
Not available
S-EPMC9074265 | biostudies-literature
ProteomicsLC-MSMS analysis of bear muscle mitochondria during hibernation
During hibernation, the physiology of bears is characterized by strong metabolic depression. In skeletal muscles, lipids are used as the main energy fuels although their oxidation rate is reduced, and glycolysis appears maintained likely feeding the Cori cycle. Mitochondria no doubt play an essentia...
ORGANISM(S): Ursus arctos arctos (European brown bear) 
2026-03-02 | PXD036916 | Pride
Lc-msms Metabolic depression Temperature Bear Hibernation 
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