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ProteomicsKinase peptide discovery in MIB enriched samples using 2m monolithic silica-C18 column
This dataset accompanies our publication "An optimized chromatographic strategy for multiplexing in parallel reaction monitoring mass spectrometry: Insights from quantitation of activated kinases" in Molecular & Cellular Proteomics, 2016 (https://www.ncbi.nlm.nih.gov/pubmed/27940637). The submitted ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-04-10 | MSV000079644 | MassIVE
ProteomicsPTMs of Endogenous Tau in Wildtype and hAPP Transgenic Mice
Please Note, if a password is required, please try "a", the generic password for Massive. These data are in support of the manuscript: Post-translational Modifications of Endogenous Tau in Wildtype and Human Amyloid Precursor Protein Transgenic Mice Meaghan Morris*a,b, Giselle M. Knudsen*c, Sumi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2014-07-30 | MSV000078796 | MassIVE
ProteomicsPhosphoproteomic analysis of Hemin- and Erastin-induced neuronal death
Analysis of the differences in phosphorylation in two ferroptosis subtypes (Hemin vs classical erastin-induced ferroptosis) in neurons, and sensitivity of these changes in phosphorylation levels to treatment with ferroptosis suppressor and MEK inhibitor U0126.
ORGANISM(S): Mus musculus (Mouse) 
2022-01-28 | PXD029318 | Pride
Erastin Hemin Tmt U0126 Ferroptosis Phosphorylation 
ProteomicsTMEM16K is an interorganelle regulator of endosomal sorting.
Using proximity biotinylation proteomics based on TMEM16K/Ano10 (an endoplasmic reticulum lipid scramblase causative for spinocerebellar ataxia) BioID chimeras, we identify endosomal transport as a major functional cluster of interacting proteins.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-05-30 | PXD018990 | Pride
Bioid Endosomal sorting Tmem16k 
ProteomicsMapping Axon Initial Segment Structure and Function by Iterative Proximity Biotinylation
We constructed AIS-targeted biotin ligase by generating fusion proteins of BirA* with NF186, Ndel1, and Trim46; these chimeras mapped the molecular organization of intracellular membrane, cytosolic, and microtubule compartments of the AIS, respectively
ORGANISM(S): Rattus norvegicus (Rat) 
2020-01-13 | PXD016272 | Pride
Bioid Axon initial segments 
ProteomicsStructure of a Complete Mediator-RNA Polymerase II Pre-Initiation Complex, and the Regulation of Transcription
MedPIC: Crosslinking-MS of 54 subunit pre-initiation complex from yeast. MedPolII: Crosslinking-MS of 33 subunit Mediator + polII complex from yeast.
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2016-08-02 | MSV000080013 | MassIVE
ProteomicsA novel translocon for biogenesis of multi-pass membrane proteins
A novel 370 kDa translocon comprising Sec61 and five accessory factors acting co-translationally with ribosomes to fold and insert multi-pass membrane proteins was identified, purified and analyzed structurally by single particle cryo-EM and cross-linking mass spectrometry. The purified ribosome-tr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-07-08 | MSV000084065 | MassIVE
TranscriptomicsSignaling to Transcription Networks in the Neuronal Retrograde Injury Response
Retrograde signaling from axon to soma activates intrinsic regeneration mechanisms in lesioned peripheral sensory neurons; however, the links between axonal injury signaling and the cell body response are not well understood. Here, we used phosphoproteomics and microarrays to implicate ~900 phosphop...
ORGANISM(S): Rattus norvegicus 
2010-12-29 | E-GEOD-26350 | biostudies-arrayexpress
TranscriptomicsGlobal response to chemotherapy-induced apoptosis
Here we use an integrated systems-level examination of transcription, translation, and proteolysis to explore how cancer cells struggle with a chemotherapeutic drug prior to succumbing to apoptosis. As a model system we study myeloma cells exposed to the proteasome inhibitor bortezomib, a first-line...
ORGANISM(S): Homo sapiens 
2013-10-17 | E-GEOD-48785 | biostudies-arrayexpress
ProteomicsCapture, release, and identification of newly synthesized proteins for improved profiling of functional translatomes
Proteins undergoing active translation in proliferating K562 cells during a 2-hour time frame were labeled with O-propargyl-puromycin for subsequent click reaction with cleavable Dde biotin-azide. Following capture on streptavidin agarose resin, nascent polypeptides were released from the resin by t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-07-22 | MSV000089950 | MassIVE
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