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ProteomicsUrsodeoxycholic acid promoted TGF-β degradation
MS analysis of proteins interacting with PKA and TGF-β1 in HEK293T cells. MS analysis of immunoprecipitated TGF-β1 in HEK293T cells with TGF-β1 overexpression.
ORGANISM(S): Mus musculus (Mouse) 
2022-06-28 | PXD031801 | Pride
Tgf-β1 Pka Phosphorylation modification 
ProteomicsMass spectrometry analysis of proteins interacting with Fbxw7 in T cells
To elucidate how gut microbiota (GM) downregulated Fbxw7, we treated CD4+ T cells with GM-lysates and pulled down Fbxw7 in the cell lysates. Then, the precipitated proteins were analyzed by mass spectrometry, and eight E3 ligases were revealed to interact with Fbxw7.
ORGANISM(S): Mus musculus (Mouse) 
2025-04-16 | PXD057140 | Pride
Fbxw7  trim21  th17 cells  gut microbiota 
ProteomicsType I interferon/STAT1 signaling negative feedback regulates UBE2M-mediated antiviral innate immunity
To identify potential proteins involved in RIG-I regulation, we pulled down RIG-I from HEK293T or NIH-3T3 cells overexpressing RIG-I, and the RIG-I-bound proteins were then analyzed by mass spectrometry (MS).
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2023-01-30 | PXD039071 | Pride
Hek293t nih-3t3 lc-msms rig-i ube2m 
ProteomicsMFGE8 induces anti-PD-1-therapy resistance by promoting extracellular vesicle sorting of PD-L1
To identify which E3 ligases ubiquitinate PD-L1, we overexpressed PD-L1-Flag in HEK293 cells and used anti-Flag magnetic beads to pull down PD-L1 from cell lysates. The interacting proteins were then analyzed by mass spectrometry, revealing that three E3 ligases interact with PD-L1.
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD057691 | Pride
Anti-pd-1-therapy resistance Ube4a Extracellular vesicles Mfge8 Pd-l1 
ProteomicsMFGE8 induces anti-PD-1-therapy resistance by promoting extracellular vesicle sorting of PD-L1
To elucidate which secreted factors in tumor tissues (TTs) are responsible for the upregulation of UBE4A as the tumor progresses, we inoculated tumors in mice and analyzed the 2- and 4-week TT fluid by mass spectrometry (MS). By combining molecular weight cut off(MWCO) and the identification of secr...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058079 | Pride
Anti-pd-1-therapy resistance Ube4a Extracellular vesicles Mfge8 Pd-l1 
ProteomicsRepurposing Etalocib suppresses multidrug-resistant staphylococcus aureus
Staphylococcus aureus (S. aureus) is common gram-positive bacteria that prominently causes community acquired infection (CAI) and hospital acquired infection (HAI) makes it a versatile and dangerous, Antibiotic resistance and the long - term nature of new drug research and development have forced th...
ORGANISM(S): Staphylococcus Aureus 
2024-11-11 | PXD057734 |
ProteomicsCoro1a promotes the multivesicular body and plasma membrane fusion by facilitating PKM2-mediated SNAP-23 phosphorylation
During the formation of endosomal pathway-dependent extracellular vesicles (EVs), intraluminal vesicles in multivesicular bodies (MVBs) fuse with the plasma membrane (PM), releasing intraluminal vesicles to produce exosomes. Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNAR...
ORGANISM(S): Homo Sapiens 
2025-12-07 | PXD071700 |
ProteomicsExtracellular vesicles from Methicillin-resistant Staphylococcus aureus-infected alveolar macrophages induce necroptosis
Staphylococcus aureus (S. aureus), a major cause of hospital and community-acquired pneumonia, still has a high mortality rate. Extracellular vesicles (EVs), as crucial mediators of intercellular communication, have a significant impact on infectious diseases. However, the role of EVs from alveolar ...
ORGANISM(S): Mus Musculus 
2024-05-21 | PXD052452 |
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