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ProteomicsLight-mediated discovery of surfaceome nanoscale organization and intercellular receptor interaction networks
Delineating the extracellular interaction network of the cell surface proteotype (the surfaceome) is fundamental to understanding cellular signaling function in health and disease. Here, we developed LUX-MS, an optoproteomic technology that enables the spatiotemporal and proteome-wide study of surfa...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) Listeria monocytogenes serotype 4b Listeria phage A500 Escherichia coli 
2021-06-14 | PXD020481 | Pride
Lc-ms/ms 
ProteomicsDe novo Classification of Mouse B Cell Types using Surfaceome Proteotype Maps
System-wide quantification of the cell surface proteotype and identification of extracellular glycosylation sites is challenging when sample is limiting. We miniaturized and automated the previously described Cell Surface Capture technology increasing sensitivity, reproducibility, and throughput. We...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-12-11 | PXD013627 | Pride
Flow cytometry Cell surface capture Cell surface proteome Hrm B-cell development Dda Mouse model Classification Affinity purification Dia Lc-ms Proteotype Autocsc Csc Surfaceome 
ProteomicsUltrafast and Chemoselective Biotinylation of Living Cell Surface for Time-Resolved Surfaceome Analysis - final
Cell surface proteins participate in many important biological processes such as cell-to-cell interaction, signal transduction, cell adhesion, and protein transportation. In-depth study of the cell surface protein group is of great significance. Nevertheless, detection and analysis of the surfaceome...
ORGANISM(S): Homo Sapiens 
2024-07-06 | PXD053733 |
ProteomicsHeart surfaceome profiling using biotin capture
Cell surface proteins (surfaceome) represent key signalling and interaction molecules for therapeutic targeting, biomarker profiling, and cellular phenotyping. Understanding the surfaceome of complex tissues including the heart is essential to investigate membrane composition and function in physiol...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000095912 | MassIVE
ProteomicsSurfaceome proteomic of glioblastoma revealed potential targets for immunotherapy
Glioblastoma (GBM) is the most common and devastating malignant brain tumor in adults. The mortality rate is very high despite different treatments. New therapeutic targets are therefore highly needed to improve patient care. Cell-surface proteins represent attractive targets due to their accessibil...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD027110 | Pride
Surface proteins Glioblastoma Mutated proteins Surfaceome Immunotherapy 
ProteomicsThe surfaceome of chondrogenic cells
Chondrogenesis, the process through which cartilage forms, has implications for cartilage repair and osteoarthritis (OA) management. In this study, we present the first comprehensive quantitative analysis of the surfaceome of chondrogenic cells using a well-established in vitro chondrogenic model. B...
ORGANISM(S): Gallus gallus (Chicken) 
2026-01-19 | PXD064013 | Pride
Glycocapture Osteoarthritis Cartilage Surfaceome  chondrogenesis Cartilage regeneration 
ProteomicsExoproteome and surfaceome of toxigenic Corynebacterium diphtheriae 1737 and their response to iron-restriction and growth on human hemoglobin
Diphtheria is a severe upper respiratory disease that can cause fatal infections. It is known to produce diphtheria toxin and a range of other virulence factors, particularly when it encounters low levels of iron at sites of infection. Genomic sequencing of the NCTC13129 reference strain and its rel...
ORGANISM(S): Corynebacterium diphtheriae NCTC 13129 Bacteria 
2025-05-06 | PXD051674 | Pride
Proteomics Cell surface Diphtheria Label-free quantification Exoproteome Differential expression Corynebacterium diphtheriae Cell envelope Surface proteome Proteomic profiling Virulence factors 
ProteomicsProfiling the surfaceome identifies therapeutic targets for cells with hyperactive mTORC1 signaling
Aberrantly high mTORC1 signaling is a known driver of many cancers and human disorders, yet pharmacological inhibition of mTORC1 rarely confers durable clinical responses. To explore alternative therapeutic strategies, herein we conducted a proteomics survey to identify cell surface proteins upregul...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-06-17 | MSV000083988 | MassIVE
UnknownBioinformatics construction of the human cell surfaceome.
Not available
S-EPMC2757864 | biostudies-literature
ProteomicsChinese hamster ovary (CHO) cell Surfaceome LC-MSMS and mRNA expression analysis
The production of biopharmaceuticals relies on robust cell systems that can produce recombinant proteins at high levels, and grow and survive in the stressful bioprocess environment. Chinese hamster ovary cells (CHO) as the main production hosts offer a variety of advantages including robust growth ...
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2022-10-15 | PXD033581 | Pride
Lc-msms Signaling pathways Mrna expression Cho cells Surfaceome 
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