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MetabolomicsCell type-specific proteomics uncovers a RAF15-SnRK2.6/OST1 kinase cascade in guard cells

Multicellular organisms such as plants contain various cell types with specialized functions. Analyzing the characteristics of each cell type reveals specific cell functions and enhances our understanding of organization and function at the organismal level. Guard cells (GCs) are specialized epid...

2024-09-03 | MTBLS3997 | MetaboLights
ProteomicsiCAB: Development of an in situ cell-type specific proteome analysis method using antibody-mediated biotinylation
Since proteins are essential molecules exerting cellular functions, decoding proteome changes is the key to understanding the normal physiology and pathogenesis mechanism of various diseases. However, conventional proteomic studies are often conducted on tissue lumps, in which multiple cell types ar...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-12 | PXD046362 | Pride
Neuron Astrocytes Microglia. Brain Mass spectrometry Cell-type-specific proteome analysis Immunohistochemistry Biotin-tyramide 
GenomicsCombined transcriptome and proteome profiling reveal cell-type-specific functions of Drosophila garland and pericardial nephrocytes
Combined transcriptome and proteome profiling reveal cell-type-specific functions of Drosophila garland and pericardial nephrocytes
PRJNA1051627 | ENA
ProteomicsFANS unfixed: isolation and proteomic analysis of mouse cell type-specific brain nuclei
Epigenetic-mediated gene regulation orchestrates brain cell-type gene expression programmes, and epigenetic dysregulation is a major driver of aging and disease-associated changes. Proteins that mediate gene regulation are mostly localised to the nucleus, however, nuclear-localised proteins are ofte...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-09 | PXD053515 | Pride
Cell-type specific Proteomics Neurons Fans Microglia Epigenetics Oligodendrocytes 
MetabolomicsGolgi-IP, a tool for multimodal analysis of Golgi molecular content
The Golgi is a membrane-bound organelle that is essential for protein and lipid biosynthesis. It represents a central trafficking hub that sorts proteins and lipids to various destinations or for secretion from the cell. The Golgi has emerged as a docking platform for cellular signaling pathways inc...
2023-06-27 | MTBLS6511 | MetaboLights
UnknownDevelopment of an in situ cell-type specific proteome analysis method using antibody-mediated biotinylation.
Not available
S-EPMC10312661 | biostudies-literature
ProteomicsCell-type and subcellular compartment-specific APEX2 proximity labeling reveals activity-dependent nuclear proteome dynamics in the striatum
The vertebrate brain consists of diverse neuronal types, classified by distinct anatomy and function, along with divergent transcriptomes and proteomes. Defining the cell-type specific neuroproteome is important for understanding the development and functional organization of neural circuits. This t...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-10 | PXD022335 | Pride
Striatum Proximity labeling Apex2 Neurproteomics 
ProteomicsCombined transcriptome and proteome profiling indicate cell-type-specific functions of Drosophila garland and pericardial nephrocytes
Drosophila nephrocytes are specialised cells that share critical functional, morphological, and molecular features with podocytes of the mammalian kidney, including the slit diaphragm, which is a functional filtration barrier. Accordingly, nephrocytes are considered highly suitable invertebrate mode...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2024-10-08 | PXD047262 | Pride
Labyrinth channels Transcriptome Ageing Kidney model Nephropathies Nephrocytes Slit diaphragms Proteome Drosophila melanogaster 
ProteomicsCell type-specific metabolic labelling of nascent proteomes in vivo
Changes in protein expression drive both the acute responses and long-lasting adaptation of cells to internal and external stimuli. While advances in labelling strategies have made it possible to examine general proteome dynamics, it is still not possible to access the proteomes of specific cell typ...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-10 | PXD007703 | Pride
Anl Boncat Azidonorleucine Nascent proteomes Funcat Metabolic labeling 
ProteomicsProtein abundance of AKT and ERK pathway components governs cell-type-specific regulation of proliferation
Signaling through the AKT and ERK pathways controls cell proliferation. However, the integrated regulation of this multistep process, involving signal processing, cell growth and cell-cycle progression, is poorly understood. Here we study different murine hematopoietic cell types, in which AKT and E...
ORGANISM(S): Homo sapiens (Human) 
2017-01-30 | PXD004816 | Pride
Human Cfu-e Proteome ruler Label-free quantification 
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