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TranscriptomicsComparative analysis of transcripts from mia40-4int mutant and wild-type Saccharomyces cerevisiae strains quantified in RNA-seq experiment
The vast majority of the mitochondrial proteome originates from nuclear genes and is transported into the organelle after synthesis in the cytosol. Complex machineries, which maintain the specificity of protein import and sorting exist. Dysfunctions of mitochondrial protein sorting pathways result i...
ORGANISM(S): Saccharomyces cerevisiae 
2015-07-31 | E-MTAB-3588 | biostudies-arrayexpress
MetabolomicsIntegrated proteome and lipidome analyses place OCIAD1 at mitochondria-peroxisome intersection balancing lipid metabolism

OCIAD1 (Ovarian Cancer Immunoreactive Antigen Domain Containing 1) is a membrane protein largely localized to mitochondria, however, its function in health or disease is not well understood. To comprehensively characterize the molecular changes upon lack of OCIAD1, we used mass spectrometry to st...

2025-04-25 | MTBLS12329 | MetaboLights
ProteomicsIdentification of binding partners of the purified TOM complex from HEK293T cells
To investigate the interactome of the human translocase of the outer mitochondrial membrane (TOM) complex, we performed immunoaffinity purification of TOMM22-FLAG from HEK293T cells followed by LC-MS/MS analysis. This approach allowed us to identify proteins that co-purify with the TOM complex under...
ORGANISM(S): Homo sapiens (Human) 
2026-03-17 | PXD064520 | Pride
Tom complex Tomm22-flag ip Hek293t 
ProteomicsChanges in Caenorhabditis elegans proteome after dnj-21 knockdown
Dysfunction of the motor subunit of the TIM23 translocase, the PAM complex located on the matrix side of the mitochondrial inner membrane in Saccharomyces cerevisiae, was shown to cause a decrease in mitochondrial protein import and precursor accumulation in the cytosol. We used an analogous model t...
ORGANISM(S): Homo sapiens (Human) Caenorhabditis elegans 
2021-05-19 | PXD023830 | Pride
Caenorhabditis elegans Dnj-21 knockdown Mitochondria Mitochondrial stress 
ProteomicsProteomic analysis of FKBP8 knockdown in HEK293T cells
To investigate the effects of FKBP8 depletion in HEK293T cells, cells were transfected with siRNA targeting FKBP8 or with a non-targeting control siRNA for 48 hours. After transfection, cells were collected; 10% of the material was used for whole-cell proteome analysis, and the remaining 90% was use...
ORGANISM(S): Homo sapiens (Human) 
2026-03-17 | PXD070730 | Pride
Fk506-binding protein Knockdown Fkbp8 Mitochondria Hek293t 
ProteomicsLoss of the Mia40a oxidoreductase leads to hepato-pancreatic insufficiency in the zebrafish
Development and function of tissues and organs are powered by the activity of mitochondria. In humans, inherited genetic mutations that lead to progressive mitochondrial pathology often manifest during infancy and can lead to death, reflecting the indispensable nature of mitochondrial function and ...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2018-10-10 | PXD009594 | Pride
Proteomics Danio rerio Mia pathway Dimethyl labeling (dml) Mitochondria Biological 
ProteomicsHuman OCIAD2 binding partners and the effect of OCIAD2 depletion on mitochondrial protein levels
Assembly of the oxidative phoshorylation dimeric complex III (CIII2) in the mitochondrial inner membrane is an intricate process in which many factors are involved. Despite many studies this process is yet to be completely understood. Here we report the identification of human OCIAD2 (Ovarian Carcin...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD023025 | Pride
Oxidative phosphorylation Mitochondria Ociad2 Oxphos complex iii 
ProteomicsShotgun analysis of proteins co-immunoprecipitating with OCIAD1-FLAG
Interactome of OCIAD1-FLAG was studied. TMT-based relative quantification of protein levels was performed in eluates from mitochondria of HEK293 cells that expressed OCIAD1-FLAG vs empty vector and from mitochondria of OCIAD1-KO cells that expressed OCIAD1-FLAG vs empty vector.
ORGANISM(S): Homo sapiens (Human) 
2024-11-08 | PXD043863 | Pride
Coip Ociad1 Mitochondria Hek293 
ProteomicsIntegrated proteome and lipidome analyses place OCIAD1 at mitochondria-peroxisome intersection balancing lipid metabolism
OCIAD1 (Ovarian Cancer Immunoreactive Antigen Domain Containing 1) is a membrane protein largely localized to mitochondria, however, its function in health or disease is not well understood. To comprehensively characterize the molecular changes upon lack of OCIAD1, we used mass spectrometry to study...
ORGANISM(S): Homo sapiens (Human) 
2025-04-18 | PXD061576 | Pride
Mitochondrial biology Lipidomics Lipid metabolism Proteomics Peroxisomes 
ProteomicsAlterations in the nascent proteome during translation attenuation in response to mitochondrial stress induced by carbonyl cyanide m-chlorophenyl hydrazine (CCCP) and in response to EEF1A1 knockdown
This submission is a part of a proteomic resource consisting of four independent datasets and their meta-analysis which describe: the detailed landscape of changes in the nascent proteome at high temporal resolution with 30 min intervals upon rapid and reversible global translation attenuation in re...
ORGANISM(S): Homo sapiens (Human) 
2024-10-02 | PXD054502 | Pride
Mitochondria Eef1a1 elongation factor Mitochondrial stress Nascent proteome Cccp 
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