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ProteomicsC1QBP mitochondrial interactome
The study of protein-protein interactions is an essential process to understand the biological functions of proteins and the underlying mechanisms. Co-immunoprecipitation coupled with mass spectrometry (CoIP-MS) is one of the most extensively used high-throughput techniques to discover novel protein...
ORGANISM(S): Homo Sapiens 
2015-11-04 | MSV000079369 | MassIVE
ProteomicsYBX1 interacting protein - C1QBP Negatively Regulates the Activation of Oncoprotein YBX1 in the Renal Cell Carcinoma As Revealed by Interactomics Analysis
The Y-box-binding protein 1 (YBX1) plays a critical role in tumorigenesis by promoting cell proliferation, overriding cell-cycle check points, and enhancing genomic instability. In this study, the interactome of YBX1 in renal cell carcinoma (RCC) was analyzed by coimmunoprecipitation and mass spectr...
ORGANISM(S): Homo sapiens (Human) 
2015-01-30 | PXD001493 | Pride
Human Renal cancer Ybx1 Lc-ms/ms 
ProteomicsDeciphering the Protein-Protein Interaction Network Regulating Hepatocelluler Carcinoma Metastasis
Hepatocellular carcinoma (HCC) is one of the leading causes of mortality related to cancer all over the world. The poor prognosis of HCC is mostly due to recurrence and tumor metastasis. In order to better understand the molecular mechanisms of HCC metastasis, we analyzed the proteome of three HCC c...
ORGANISM(S): Homo sapiens (Human) 
2017-06-20 | PXD005647 | Pride
Dimethylation  hcc  lc-ms/ms  protein-protein interaction  quantitative proteomics  tumor progression 
ProteomicslncRNA MALAT1 interactome - Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long non-coding RNA (lncRNA) that was first discovered as a prognostic marker for lung cancer metastasis. MALAT1 has been implicated in the tumorigenesis of numerous tumor types. To further delineate the underlying molecular mechan...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD005154 | Pride
Rna pulldown Malat1 Lncrna Lc-ms/ms 
ProteomicsQuantitative proteomic analysis of oxaliplatin induced peripheral neurotoxicity
We performed a data independent acquisition (DIA) -based quantitative proteomics strategy to investigate the global proteome alteration in the dorsal root ganglion (DRG) tissues from mice injected with oxaliplatin for different periods.
ORGANISM(S): Mus musculus (Mouse) 
2022-07-11 | PXD031322 | Pride
Metabolism Peripheral neurotoxicity Oxaliplatin Ros Quantitative proteomics 
ProteomicsQuantitative proteomic analysis of experimental autoimmune encephalomyelitis mice implicates SUMOylation in multiple sclerosis
In this study, we performed quantitative proteomics utilizing a data-independent acquisition (DIA) strategy to investigate the proteome alteration in the brain and spinal cord tissues from mice with experimental autoimmune encephalomyelitis (EAE), a widely-used model for MS.
ORGANISM(S): Mus Musculus 
2024-03-20 | PXD050789 |
ProteomicsQuantitative proteomics and phosphoproteomics reveal that PIM3 modulates cell migration via regulating Rho GTPase signaling
For the phosphoproteomic analysis, three biological replicates and two technical replicates were analyzed, resulting in twelve data for quantification. Statistical analysis was performed using student’s t-test as described in details in the “LC-MS/MS and data analysis” section
ORGANISM(S): Homo sapiens (Human) 
2020-02-04 | PXD014044 | Pride
Human Lc-ms/ms Liver Cell 
ProteomicsQuantitative proteomics and phosphoproteomics reveal that PIM3 modulates cell migration via regulating Rho GTPase signaling
Stable cell line was used for this study, so there are minimum variations between samples. For the lable free based quantitative analysis of the whole proteome, three biological replicates for each condition were investigated. For the phosphoproteomic analysis, three biological replicates and two te...
ORGANISM(S): Homo sapiens (Human) 
2020-02-04 | PXD014045 | Pride
Pim3 rho gtpase 
ProteomicsHULC interactome MS analysis
we report a high throughput strategy to screen for lncRNA interacting proteins in vivo by combining tobramycin affinity purification and mass spectrometric analysis (TOBAP-MS). This method was applied to establish the interactome network for the lncRNA highly-upregulated in liver cancer (HULC).
ORGANISM(S): Homo sapiens (Human) 
2020-07-02 | PXD012927 | Pride
Hulc Silac Gel-based proteomics 
ProteomicsIn-depth Profiling and Quantification of the lysine acetylome in Hepatocellular Carcinoma with a Trapped Ion Mobility Mass Spectrometer
This is supplemental data of “ In-depth Profiling and Quantification of the lysine acetylome in Hepatocellular Carcinoma with a Trapped Ion Mobility Mass Spectrometer ” project. In this data, we employed an integrated proteomics and acetylomics strategy to characterize of three Huh7 cells (NC1, NC2,...
ORGANISM(S): Homo sapiens (Human) 
2022-07-02 | PXD031636 | Pride
Pasef Proteomics Acetylomics Hepatocellular carcinoma Sirt2 Timstof pro. Non-histone Cellular metabolism 
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