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ProteomicsRepression of PRMT5-mediated dimethylation stabilizes vimentin and promotes metastasis in MTAP-loss lung cancer
Abstract The aggressive nature and poor prognosis of lung cancer led us to explore the mechanisms driving disease progression. Utilizing our invasive cell-based model, we identified methylthioadenosine phosphorylase (MTAP) and confirmed its suppressive effects on tumorigenesis and metastasis, and pa...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD031192 | Pride
Human Dimethylation Lung cancer 
ProteomicsMouse Skin LC-MS/MS
Previously, we reported that a null mutation of the Zdhhc13 gene caused by ethylnitrosourea (ENU) mutagenesis in mice resulted in severe systematic phenotypes with amyloidosis, alopecia, dermatitis and osteoporosis. In this study we continued to delineate the pathological mechanism for the dermatiti...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-25 | PXD002958 | Pride
Mouse skin tissue Palmitoylation Lc-ms/ms 
ProteomicsEndogenous S-nitrosoproteome in colorectal cancer patients
Total lysate of tumorous and adjacent normal tissues from each colorectal cancer patient are followed by S-alkylating biotin switch strategy. All biotinylated peptides are analyzed by label-free quantitation and LC-MS/MS analysis. All peak lists from 66 raw MS/MS spectra were processed to mgf format...
ORGANISM(S): Homo sapiens (Human) 
2014-08-20 | PXD000467 | Pride
Tissue S-nitrosylation Biotin switch Human Colorectal cancer 
ProteomicsIdentification of Siglec-E-ligand candidates on BCL-1 mouse B cell line by proximity labeling
Siglec-E is a member of Siglec family of glycan recognition proteins involved in the regulation of myeloid cell activities. Siglec-E preferentially recognizes disialic acid, a glycan epitope consisting of two sialic acids conjugated in alpha2-8 linkage (Zhang JQ et al., Eur J Immunol. 2004, 34:1175...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-25 | PXD013032 | Pride
Lc-msms Siglec-e Mouse Ligand B cell Sialic acid 
ProteomicsMetal ion-decorated ZIC-cHILIC StageTip Enables Simultaneous Profiling of N-Glycoproteome and Phosphoproteome in TKI resistant NSCLC cells
Cell membrane proteins are densely decorated with surface glycosylation and intracellular phosphorylation whose interplay determines the cell-cell communication and signaling cascades. However, their concomitant characterization remains extreme challenges due to complexity of glycan structures, low ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD056077 | Pride
Phosphoproteome N-glycoproteome Zic-chilic 
ProteomicsMouse Liver S-Palmitoylation ZDHHC13 LC-MS/MS
Protein S-palmitoylation is a reversible post-translational modification which adding 16-carbon palmitate to specific cysteines and contributes to variable biological functions such as protein trafficking, scaffolding and signaling. ZDHHC13 is one of the members of DHHC-containing palmitoyl-acyltran...
ORGANISM(S): Mus musculus (Mouse) 
2017-09-29 | PXD003039 | Pride
Zdhhc13 Mouse S-palmitoylation Liver Lc-ms/ms 
ProteomicsSerpinB2/TPPII regulates senescence
Tripeptidyl peptidase II (TPPII) degrades N-terminal tripeptides from proteins and peptides. Studies in both human and mice have shown that TPPII deficiency is linked to cellular immune-senescence, lifespan regulation, and the aging process. However, the mechanism of how TPPII participates in these ...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD033808 | Pride
Activity-based probe  serine hydrolase  tpp  senescence  benzylphosphonofluoridate 
ProteomicsGlycoproteome of Human lung cancer cell by LC-MSMS
We demonstrate the utility of lectin-magnetic nanoprobe coupled with Orbitrap HCD-CID-MS/MS for complementary glycotope-specific enrichment and site-specific glycosylation analysis of the glycoproteome. Using non-small cell lung cancer (NSCLC) cells as model, this approach allowed us to compare the ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-25 | PXD010035 | Pride
Lc-msms Lung cancer cell Human Glycoproteom 
ProteomicsSialo-glycoproteome of Human lung cancer cell by LC-MSMS
Alterations in protein glycosylation, especially the terminal sialylation, are closely correlated with physiological and pathological regulation. Due to the low ionization efficiency of sialo-glycopeptides and frequently observed dissociation of sialic acid residues during mass spectrometry analysis...
ORGANISM(S): Homo sapiens (Human) 
2022-02-25 | PXD010456 | Pride
Sialo-glycoproteome Glycoproteome Human lung cancer 
ProteomicsIdentification of Siglec ligands in human B cell
Siglecs are a family of receptor-type glycan recognition proteins (lectins) involved in self - nonself discrimination by the immune system. Identification of Siglec ligand(s) is necessary to understand how Siglec-ligand interaction translates to biological outcomes, but is challenging because the in...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-09-29 | PXD006359 | Pride
Proteomics Siglec Sialic acid 
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