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GenomicsH3K27me3 ChIP-seq experiment in fruitfly testis somatic gonadal cells
In many metazoans, germ cells are separated from somatic lineages early in development and maintain their identity throughout life. Here we show that a Polycomb group (PcG) component, Enhancer of Zeste [E(z)] H3K27me3-specific methyltransferase, maintains germline identity in Drosophila adult testes...
ORGANISM(S): Drosophila melanogaster 
2014-05-02 | E-GEOD-53238 | biostudies-arrayexpress
UnknownAnalysis of the Underlying Mechanism of the Jiu Wei Zhen Xin Formula for Treating Generalized Anxiety Disorder Based on Network Pharmacology of Traditional Chinese Medicine.
Not available
S-EPMC9168090 | biostudies-literature
UnknownProximal Tibial Cortex Transverse Distraction Facilitating Healing and Limb Salvage in Severe and Recalcitrant Diabetic Foot Ulcers.
Not available
S-EPMC7282570 | biostudies-literature
ProteomicsNaringenin Suppresses BEAS-2B-derived Exosomal Cargoes Disorder Caused by Cigarette Smoke Extract thereby Inhibiting M1 Macrophage Polarization
Effects of cigaratte smoke extract and naringenin on the exosomal proteome derived from human airway epithelial cells
ORGANISM(S): Homo sapiens (Human) 
2022-07-13 | PXD033545 | Pride
Exosome Naringenin Epithelium-macrophage crosstalk Cigarette smoke Macrophage polarization 
UnknownShi-Zhen-An-Shen Decoction, a Herbal Medicine That Reverses Cuprizone-Induced Demyelination and Behavioral Deficits in Mice Independent of the Neuregulin-1 Pathway.
Not available
S-EPMC7932787 | biostudies-literature
UnknownInterleukin-18 genetic polymorphisms contribute differentially to the susceptibility to Crohn's disease.
Not available
S-EPMC4515852 | biostudies-literature
ProteomicsHuman DNA Mismatch Repair pathway LC-MSMS
The mismatch repair (MMR) family is a highly conserved group of proteins that function in correcting base-base and insertion-deletion mismatches generated during DNA replication. To systematically investigate the mismatch repair pathway, we conducted a proteomic analysis and identified MMR-associate...
ORGANISM(S): Homo sapiens (Human) 
2016-02-08 | PXD003014 | Pride
Human Hek-293t Tap Mmr 
ProteomicsSLX4 and SLX4IP TAP-MS - SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair
Interstrand crosslinks (ICLs) are highly toxic DNA lesions, which are repaired via a complex process that requires the coordination of several DNA repair pathways. Defects in ICL repair result in Fanconi anemia (FA), which is diagnosed with bone marrow failure, development abnormalities and high inc...
ORGANISM(S): Homo sapiens (Human) 
2019-09-13 | PXD012521 | Pride
Sfb Slx4 Tap-ms Slx4ip 
ProteomicsPCNA interactome - SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair
We examined the complexity of replication fork composition upon DNA damage by employing a PCNA-based proteomic screen to uncover known and new players involved in replication and replication stress response. We used camptothecin or ultraviolet radiation, that lead to fork-blocking lesions, to establ...
ORGANISM(S): Homo sapiens (Human) 
2018-12-14 | PXD011727 | Pride
Pcna Bioid Interactome 
ProteomicsGlobal Phosphoproteomic Analysis Reveals ARMC10 as an AMPK Substrate that Regulates Mitochondrial Dynamics
AMP-activated protein kinase (AMPK) is a key regulator of cellular energy homeostasis. Although AMPK has been studied extensively in cellular processes, understanding of its substrates and downstream functional network, and their contributions to cell fate and disease development, remains incomplete...
ORGANISM(S): Homo sapiens (Human) 
2019-01-16 | PXD011696 | Pride
Phosphoproteomics Ampk Silac Lc-ms/ms 
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